Metabolic Flexibility, Eating Behavior and Adipose Tissue Expandability: Role of This Triad in the Propensity to Human Obesity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 59
- 试验地点
- 1
- 主要终点
- Total ad-libitum energy intake
研究概览
简要总结
This study evaluates eating behavior and metabolic responses following consumption of a high-fat high-energy meal in healthy underweight and normal-weight adults. The primary research question is: Do healthy underweight individuals exhibit different eating and metabolic responses compared with normal-weight adults following consumption of a high-fat high-energy meal?
详细描述
Healthy underweight individuals have a body mass index below the normal range in the absence of a medical condition, food aversion, food insecurity, or evidence of unusually high levels of physical activity. Although the environmental factors contributing to their lower body mass index are not fully understood, these individuals may represent a phenotype resistant to the obesogenic environment. If so, the biological mechanisms underlying this resistance remain poorly understood. Such mechanisms must ultimately influence energy expenditure, energy intake, or both.
This study will compare metabolic responses and eating behavior during fasting and following consumption of a high-fat, high-energy meal in healthy underweight and normal-weight adults. Eating behavior will be assessed through measures of food liking, subjective appetite perceptions, and ad libitum energy intake. Metabolic responses will include assessments of energy expenditure, substrate oxidation, and circulating metabolites and hormones.
We hypothesize that healthy underweight individuals will exhibit greater postprandial satiety and lower ad libitum energy intake than normal-weight adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 25 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men or women
- •Age 18-25 years
- •Stable body weight during the previous 6 months (±2 kg)
- •Healthy according to medical history and laboratory assessments
- •BMI: 15.0-<18.5 kg/m2 or 20.0-<25.0 kg/m2
排除标准
- •Pregnancy or lactation
- •Athletes or individuals engaged in high levels of physical activity, including those participating in competitive sports, structured endurance training, or physically demanding occupations.
- •Cardiovascular, liver, kidney, thyroid, or other chronic diseases requiring medical treatment
- •Conditions affecting energy metabolism or eating behavior
- •Smoking or alcohol abuse
- •Phobia or vasovagal response associated with blood draws
- •Intolerance or allergy to peanuts, chocolate, eggs, or gluten
- •Irregular menstrual cycles (>3 months without menstruation)
- •Current or previous diagnosis of eating disorders
- •Psychiatric disorders requiring antidepressant or psychotropic treatment
- •Additional criterion for healthy underweight participants:
- •Absence of food insecurity
- •Low body weight not attributable to eating disorders or exercise-related behaviors
结局指标
主要结局
Total ad-libitum energy intake
时间窗: The feeding test will be conducted 6.5 hours after the high-fat, high-energy meal.
Total energy intake consumed during the ad libitum feeding test. Participants will be provided with a selection of foods and instructed to eat ad libitum until comfortably satiated. The weight of each food item will be recorded before and after consumption, and intake will be determined from the difference. Total energy intake (kcal) will be calculated from the nutrient composition of the foods consumed using standard energy conversion factors.
次要结局
- Body composition(Measured during a dedicated body composition assessment visit.)
- Food liking(Measured during the screening visit.)
- Subjective appetite sensations(Repeatedly measured during the metabolic test before and following consumption of the high-fat, high-energy meal.)
- Energy expenditure and fuel oxidation(Repeatedly measured during the metabolic test before and following consumption of the high-fat, high-energy meal.)
- Circulating metabolite and hormonal concentrations(Repeatedly measured during the metabolic test before and following consumption of the high-fat, high-energy meal.)
研究者
Jose Galgani
Responsible Principal Investigator
Pontificia Universidad Catolica de Chile