Effect of Hypocalcemia on the Outcome of Elderly Major Trauma Patients With Trauma-induced Coagulopathy
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 371
- 试验地点
- 1
- 主要终点
- Internationalized Normalized Ratio (INR)
研究概览
简要总结
Hypocalcaemia is an independent risk factor of TIC in elderly trauma patients. TIC combined with hypocalcemia had worse coagulation function and more serious acidosis.
详细描述
This 5-year retrospective, observational, single-center study was conducted at the Second Affiliated Hospital of Zhejiang University Medical School (SAHZU, China). Elderly patients with trauma were registered when they were admitted into intensive care unit affiliated to department of Emergency medicine (EICU) since January 2015 and September 2020.The purpose of this study is to elucidate the effect of hypocalcemia on TIC in elderly trauma patients through a single-center retrospective study, so as to further optimize the diagnosis and treatment strategies for TIC in elderly trauma patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 65 Years 至 100 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age≥65 years old
- •history of trauma
排除标准
- •previous anticoagulants or antiplatelet medication;
- •Coagulopathy caused by previous underlying diseases;
- •Blood products transfused before admission;
- •Cardiac arrest on admission;
- •Malignant tumor;
- •Data incomplete
结局指标
主要结局
Internationalized Normalized Ratio (INR)
时间窗: 24 hour
coagulation function :Internationalized Normalized Ratio (INR)
Activated Partial Thromboplastin Time (APTT)
时间窗: 24 hour
coagulation function : Activated Partial Thromboplastin Time (APTT)
Prothrombin Time (PT)
时间窗: 24 hour
coagulation function : Prothrombin Time (PT)
次要结局
- Blood products rate(through study completion, an average of 1 week)