NCT02728336暂停不适用
MRI Assessment of Patient Suitability for Cardiac Resynchronization Therapy (CRT)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Derivation of score of patient suitability for CRT
研究概览
简要总结
The goals of this project are to: 1) explore the potential use of magnetic resonance imaging (MRI) data for improved prediction of response to cardiac resynchronization (CRT), and 2) use the MRI-derived data together with a computer model of the cardiovascular system to study the relative roles of different factors in the mechanical effects of dyssynchrony in failure, and in the response (or lack thereof) to CRT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and female patients ages 18 and over scheduled by conventional criteria (symptomatic impairment of cardiac function with broadened QRS) for clinical CRT procedures at NYULMC.
- •Normal kidney function as determined by GFR levels.
- •Inclusion Criteria for Controls
- •Normal kidney function as determined by GFR levels
- •No significant cardiovascular disease or risk factors.
排除标准
- •electrical implants such as cardiac pacemakers or perfusion pumps
- •ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants
- •ferromagnetic objects such as jewelry or metal clips in clothing (which will be removed)
- •pre-existing medical conditions including a likelihood of developing seizures or claustrophobic reactions, and any greater than normal potential for cardiac arrest.
结局指标
主要结局
Derivation of score of patient suitability for CRT
时间窗: 4 Years
Binary logistic regression and receiver operating characteristic curve (ROC) analyses will be used to assess the utility of baseline (pre-CRT) MRI-derived measures, alone and in combination, for the prediction of response to CRT.
次要结局
未报告次要终点
研究者
研究点 (1)
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