Evaluate the Evolution of Cutaneous Discomfort of the Body and Scalp After 3 Wraps, in Patients With Moderate to Very Severe Hereditary Ichthyosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Skin discomfort Analogue Visual Scale (AVS)
研究概览
简要总结
Ichthyosis is a group of rare and chronic genetic diseases beginning at birth, in which the patient's skin is covered with scales of variable appearance and severity. This disease is disabling. The treatment is symptomatic and is based on the daily application of moisturizing creams with a high lipid content. Nevertheless, the effectiveness of these treatments is limited and are considered very painful by the patients. Wraps are local treatments carried out by specialized nurses and which consist in, following a therapeutic bath, applying a large quantity of cream to the whole body, followed by an occlusion. This type of care is simple to perform, but requires nursing expertise, to date, it is not carried out in standard practice in France, which is why the investigateur wish to evaluate the effect of wraps on different parameters reflecting the skin condition in the short and medium term.
详细描述
Ichthyosis is a group of rare and chronic genetic diseases beginning at birth, in which the patient's skin is covered with scales of variable appearance and severity. There are 2 distinct typical profiles: patients with thick scales without erythroderma and patients with finer scales on an erythrodermic background. This disease is disabling, in particular due to sensations of pruritus, skin pain and the possible presence of associated extra-cutaneous abnormalities. The treatment is symptomatic and is based on the daily application of moisturizing creams with a high lipid content for better effectiveness, keratolytic creams, and for severe forms, oral retinoids may be necessary. The creams improve the condition of the skin and reduce the sensations of skin discomfort, pain and pruritus, nevertheless, the effectiveness of these treatments is limited and are considered very painful by the patients.
Wraps are local treatments carried out by specialized nurses and which consist in, following a therapeutic bath, applying a large quantity of cream to the whole body, followed by an occlusion. The type of cream is adapted to the area of application: thus, an emollient cream is used for the body; a cream enriched with keratolytic active ingredients is used for the feet in the event of hyperkeratosis, and an emollient cream possibly enriched with keratolytic active ingredients is used for the scalp, followed by an exposure time under a steam helmet to remove scales. This type of care is simple to perform, but requires nursing expertise, to date, it is not carried out in standard practice in France, except in the centers of Toulouse, Bordeaux and Necker and at the thermal cure of Avène-les-Bains. However, the interest of such a treatment has never been evaluated independently, which is why in this study the investigators want to evaluate the effect of carrying out a daily treatment over 3 consecutive days, on different parameters reflecting the skin condition in the short and medium term
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 15 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with hereditary ichthyosis regardless of the clinical form
- •Patient with a scaling or erythema score > 6/16
- •Patient with a skin discomfort score > 3/10
- •Patient having given written, free and informed consent
- •Patient affiliated to a social security scheme
排除标准
- •Patient with a skin disease other than ichthyosis
- •Patient having modified his treatments for ichthyosis in the month preceding inclusion
- •Patient with known intolerance or allergy to one of the topicals used in the study
- •Patient unable to complete the study questionnaires
- •Patient under a protection regime
研究组 & 干预措施
Wraps (body and feet) as well as scalp care
The skin care consisting of wraps (body and feet) and scalp care, will be carried out consecutively over 3 days, in the hospital (outpatient or in day/traditional hospitalization).
干预措施: Cutaneous wraps (Procedure)
结局指标
主要结局
Skin discomfort Analogue Visual Scale (AVS)
时间窗: day 11
Percentage of patients showing a reduction of at least 3 points of their skin discomfort in the entire body, measured with the AVS scale (0-10) of cutaneous discomfort between baseline and 11 days after treatment
次要结局
- Reduction of skin discomfort - day 4(day 4)
- sweating - day 4(day 4)
- Variation of erythema and scales severity - VIIS(day 4)
- Variation of erythema and scales severity(day 4)
- Reduction of skin discomfort - day 30(day 30)
- Cutaneous pain - day 4(day 4)
- sweating - day 11(day 11)
- Cutaneous pain - day 30(day 30)
- sweating - day 30(day 30)
- Feet and scalp discomfort - day 4(day 4)
- Feet and scalp discomfort - day 11(day 11)
- pruritus - day 11(day 11)
- pruritus - day 30(day 30)
- pruritus - day 4(day 4)
- Cutaneous pain - day 11(day 11)
- Feet and scalp discomfort - day 30(day 30)
- 32-item Ichthyosis Quality of Life questionnaire (IQoL-32)(30 days after treatment)
- Variation of erythema and scales severity - Visual Index for Ichthyosis Severity(day 4)