Circuit-level mechanisms of cerebral compensation in Parkinson's disease - Cerebral compensation in Parkinson's disease

Radboud Universiteit Nijmegen0 个研究点目标入组 46 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

Trial is onging in other countries

•A person with Parkinson's disease must meet the following:
•- Idiopathic Parkinson*s disease according to UK brain bank criteria.
•- Mild to moderate disease severity (Hoehn and Yahr 1-3).
•- Dopaminergic therapy with a clear clinical response of non-tremor symptoms (bradykinesia, rigidity).
•- Right-handed
•- Normal/corrected-to-normal vision;A control subject must meet the following:
•- right handed
•- normal / corrected to normal vision
•- and be considered healthy

•- Epilepsy, convulsion or seizure (TMS)
•- Serious head trauma or brain surgery
•- Large or ferromagnetic metal parts in the head (except for a dental wire)
•- Implanted cardiac pacemaker or neurostimulator
•- Pregnancy
•- Familial epilepsy
•- Any other exclusion as per TMS screening form
•- Neurological or psychiatric co-morbidity (e.g. stroke, depression).
•- Severe head tremor or dyskinesias
•- cognitive impairment (MMSE < 26)
•- General MRI exclusion criteria (e.g. pacemaker, implanted metal parts, deep brain stimulation, claustrophobia).
•- Skin diseases at intended electrode sites (EMG)
•- Any prescribed medication that can alter cortical excitability (e.g. antiepileptics, tricyclic anti-depressives or benzodiazepines) or can have an influence on the participant*s vigilance or cognitive performance within two weeks prior to participation
•- disorders of vision

发起方