Comparison Between Multimodal and Unimodal Analgesia in Cholecystectomy
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 95
- 试验地点
- 2
- 主要终点
- Postoperative visual analogue scale (VAS)
研究概览
简要总结
Many surgical procedures are accompanied by postoperative pain with severity moderate, severe or extreme and insufficient postoperative pain control may cause risk of post-surgical complications and risk of chronic post-surgical pain The targets of preoperative pain management are to relieve patient suffering, reduce length of hospital stay and achieve early mobilization after surgery, decreasing opioid consumption and its side effects that are constipation, nausea, vomiting, dizziness, respiratory depression which is the most feared complication being life-threatening and some less common side effects as sedation
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing laparoscopic cholecystectomy
- •Patients older than 18 years old
排除标准
- •Renal or hepatic or cardiac impairment patients
- •Patients with chronic pain history
- •Allergic patients after taking aspirin or other NSAIDs
- •patients with active gastrointestinal bleeding, ulcer and inflammatory bowel diseases or cerebrovascular bleeding
研究组 & 干预措施
multimodal
pregabalin/ acetaminophen/ celecoxib
干预措施: Pregabalin 150mg (Drug)
multimodal
pregabalin/ acetaminophen/ celecoxib
干预措施: Acetaminophen 1 G Oral Tablet (Drug)
multimodal
pregabalin/ acetaminophen/ celecoxib
干预措施: Celecoxib 400Mg Oral Capsule (Drug)
unimodal
Pregabalin
干预措施: Pregabalin 150mg (Drug)
结局指标
主要结局
Postoperative visual analogue scale (VAS)
时间窗: 24 hour postoperative
The visual analog scale (VAS) is a simple and often used method for evaluating variations in pain intensity.
Amount of post operative Needed opioid analgesia
时间窗: 24 hour postoperative
ampules of opioid analgesia needed after operation
次要结局
- Type and amount of prescribed post operative non opioid analgesia(24 hour postoperative)
研究者
engy wahsh
head of clinical pharmacy unit
October 6 University