Influence of Exogenous Dietary Inorganic Nitrate on Downstream Metabolites of the Enteral Microbiome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Change of the enteral microbiome composition
研究概览
简要总结
A growing body of data shows that the enteral microbiome has an effect on cardiovascular diseases. Exogenous inorganic dietary nitrate mediates cardioprotective effects and has been shown to have an influence on the oral microbiome. The nutritional aspects of these cardioprotective effects are particularly intriguing since nitrate is abundant in our everyday diet.
Whether dietary nitrate influences the enteral microbiome and downstream metabolites like short-chain fatty acids (SCFA) and TMAO will be investigated in the present study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients aged 40-80 years
- •no regular medication intake
- •no chronic diseases
排除标准
- •Regular systemic drug intake
- •Active smoking
- •Chronic diseases
- •Acute diarrhea or vomiting
- •Short gut syndrome
- •Pregnancy or breastfeeding
研究组 & 干预措施
Nitrate
Dietary inorganic nitrate (0,12 mmol sodium-nitrate/kg BW/day) dissolved in 200 ml tap water. Supplementation for 30 days.
干预措施: Nitrate (Dietary Supplement)
结局指标
主要结局
Change of the enteral microbiome composition
时间窗: 30 days
Changes in enteral microbiome composition in stool samples at baseline and after 30 days of placebo/verum supplementation. The 16S rRNA amplicon reads obtained from an Illumina MiSeq System will be analyzed using pipeline QIIME2 (v. 2019.1).
次要结局
- Change of the oral microbiome composition(30 days)
- Change of circulating SCFA levels(30 days)