Influence of Exercise/Cardiorespiratory Fitness on Enhanced Endothelial Function With Aging: Role of Mitochondrial-derived Oxidative Stress
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 2
- 主要终点
- Change in vascular endothelial function
研究概览
简要总结
The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic exercise. In a double-blind, randomized, placebo-controlled crossover design participants with receive both MitoQ and placebo arm of the study. Primary endpoints will include vascular endothelial function assessed by brachial artery flow-mediated dilation and cardiac function assessed via pulse wave analysis. Secondary endpoints will include measures of aortic stiffness assessed by carotid-femoral pulse wave velocity and carotid artery stiffness (e.g. β-stiffness) and elasticity (carotid compliance, distensibility, and Youngs elastic modulus) from ultrasonography.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Double-blind, placebo-controlled
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Resting brachial blood pressure <160 mmHg (systolic)/<100 mmHg (diastolic)
- •Body mass index ≤ 35 kg/m2
- •Nonsmoker
- •Women must be postmenopausal defined as cessation of menses ≥ 1 year.
排除标准
- •cardiovascular/metabolic medications
- •known clinical disease
- •absolute contraindications to exercise testing
结局指标
主要结局
Change in vascular endothelial function
时间窗: Baseline and Post 1 hour
Brachial artery flow-mediated dilation (% \[relative\] and mm \[absolute\])
次要结局
- Change in carotid artery Young's elastic modulus(Baseline and Post 1 hour)
- Change in carotid artery compliance(Baseline and Post 1 hour)
- Change in carotid artery stiffness - beta-stiffness index(Baseline and Post 1 hour)
- Change in cardiovascular function(Baseline and Post 1 hour)
- Change in Aortic Stiffness(Baseline and Post 1 hour)
- Change in carotid artery distensibility(Baseline and Post 1 hour)
研究者
Brad Fleenor
Associate Professor
Ball State University