Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 318
- 试验地点
- 1
- 主要终点
- Montreal Cognitive Assessment
研究概览
简要总结
To determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health in improving global cognitive function and dual-task ability in older adults with mild cognitive impairment.
详细描述
The primary aim of the study is to determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health, relative to a standard Tai Ji Quan intervention and an exercise stretching control, in improving global cognitive function and dual-task ability among community-dwelling older adults with amnestic mild cognitive impairment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 95 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •complaint of memory loss
- •clinical dementia rating (CDR) scale score ≤0.5
- •having normal general cognitive function screened, with MMSE ≥24
- •capable of exercising safely, as determined by a healthcare provider
- •willingness to be randomly assigned to an intervention condition and complete the 24-week intervention and 6-month follow-up
排除标准
- •having medical conditions likely to compromise survival, such as metastatic cancer, or render a participant unable to engage in physical activity, such as severe cardiac failure
- •participating in any type of Tai Ji Quan or daily and/or structured vigorous physical activity (i.e., brisk walking for exercise 30 minutes or longer at a time, or engaging in muscle-strengthening activities, e.g., weight lifting on 3 or more days per week 3 months prior to the study)
研究组 & 干预措施
Cognitively enhanced Tai Ji Quan
Participants in this arm will exercise a series of Tai Ji Quan-based movements with configurations that are specifically designed for older adults to improve cognitive function, dual-task ability, strength/balance, and mobility.
干预措施: The Go for Exercise & Healthy Aging Project (Behavioral)
Standard Tai Ji Quan
Serving as an active comparison arm, participants in this intervention will exercise a series of Tai Ji Quan-based movements that are specifically designed for older adults to improve strength/balance, cognitive function, and mobility.
干预措施: The Go for Exercise & Healthy Aging Project (Behavioral)
Stretching
Serving as a control arm, participants in this intervention will engage in a series of light exercise activities consisting of breathing, stretching, and body relaxation.
干预措施: The Go for Exercise & Healthy Aging Project (Behavioral)
结局指标
主要结局
Montreal Cognitive Assessment
时间窗: baseline, 6 months
The Montreal Cognitive Assessment scale measures change in global cognitive function from baseline to 6 months. The scale scores range from 0 to 30 points, with higher scores indicating better cognitive functioning.
Montreal Cognitive Assessment
时间窗: baseline, 6 months
The Montreal Cognitive Assessment scale measures change in global cognitive function from baseline to 6 months. The scale scores range from 0 to 30 points, with higher scores indicating better cognitive functioning.
Gait Performance Under a Dual-task Condition
时间窗: baseline, 6 months
Assessing change in dual-task ability (measured in seconds) from baseline to 6 months. Change will be assessed via an Instrumental Timed Up\&Go (iTUG) gait performance (APDM, Inc.) in which the participant is asked to stand up from a chair, walk a 6-m walkway at normal pace (3 m toward a line, turn, and 3 m toward the chair), turn around, and sit down on the chair, with no cognitive task (single-task walking). The participant is then asked to perform the same procedure with a concurrent cognitive task (counting backward by 3s, starting with an odd number, e.g., 81).12 The total walking duration (in seconds) during both 6-meter walks, at normal pace, will be recorded. Lower duration indicates a better outcome.
次要结局
- Clinical Dementia Rating Scale(baseline, 6 months)
- Domain-specific Cognitive Test - Trail Making - B(baseline, 6 months)
- 4-Stage Balance Test(baseline, 6 months)
- Backward Digit Span(baseline, 6 months)
- Verbal Fluency Test(baseline, 6 months)
- Timed up and go(baseline, 6 months)
- 30-Second Chair Stands Test(baseline, 6 months)
- Forward Digit Span Test(baseline, 6 months)