Dementia and Kidney Disease: Epidemiological Approaches to Risk Factors and Treatment Strategies
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 200,000
- 试验地点
- 1
- 主要终点
- Mini Mental Status Examination
研究概览
简要总结
Kidney disease and dementia are both common in older adults, posing a significant burden on individuals and society. Growing evidence suggests that there may be links between the kidney and the brain. However, few studies have explored how these two conditions are connected in the general population. Understanding this link could help improve care for people living with either or both conditions.
This observational project aims to explore the two-way relationship between kidney disease and dementia. The main questions the investigators want to answer are:
- Does kidney disease increase the risk or worsen the progression of dementia?
- Does having dementia increase the risk or worsen the progression of kidney disease (both chronic and acute)?
- Do reno-protective drugs help protect cognitive decline?
- Do anti-dementia drugs help preserve kidney function?
To answer these questions, the investigators will analyze data collected over a period of 12 years, including people diagnosed with dementia, kidney disease, or both, using several large Swedish and international health registries:
- The Swedish Dementia Registry (SveDem)
- The Stockholm CREAtinine Measurements (SCREAM) project
- The Swedish Renal Registry (SRR)
- The GeroCovid Cohort
- The Registry of Dementia of Girona (ReDeGi)
- Cognitive impairment cohort from memory clinic, Karolinska University Hospital
This study will apply both traditional and advanced epidemiological methods, including multivariable regression, survival analysis, mixed-effects models, and machine learning (ML) techniques to examine long-term trends and associations.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Population with dementia (all type) and kidney function measurements/Chronic kidney diagnosis
排除标准
- •Population lack of important baseline and follow-up information such as year of birth and sex.
结局指标
主要结局
Mini Mental Status Examination
时间窗: MMSE will be assessed at baseline (dementia diagnosis) and at each follow-up visit every 12 months, up to 15 years or until death, whichever occurs first. Data will be reported at each time point and at study completion.
The Mini-Mental State Examination (MMSE) is a standardized test used to screen for cognitive impairment and dementia. It assesses five domains of cognitive function including: orientation, registration, attention and calculation, recall, and language. The score range from 0 to 30. A score of 23 or lower is indicative of cognitive impairment. The MMSE takes only 5-10 minutes to test. MMSE is used at both baseline and follow-up visits.
次要结局
- All-cause mortality(Will be assessed continuously from baseline up to 15 years until the end of follow-up.)
- Incidence of advanced dementia(Will be assessed annually from baseline (dementia) up to 15 years or until death, whichever occurs first.)
研究者
Hong Xu
Assistant Professor
Karolinska Institutet