Does Remote Ischemic Preconditioning Reduce the Incidence of Postoperative Atrial Fibrillation in Patient Undergoing Coronary Artery Bypass Graft Surgery?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Postoperative atrial fibrillation
研究概览
简要总结
Objectives: Despite utilization of available means for cardioprotection during cardiac surgery, myocardial injury still occurs. Further improvement of cardioprotection is therefore necessary. Remote ischemic preconditioning (RIPC) is an easy and non-invasive method. Laboratory research has shown promising results regarding myocardial survival during open heart surgery, but the clinical value of RIPC is still largely unknown. The investigators hypothesize that RIPC before coronary artery bypass grafting (CABG) reduces the incidence of postoperative atrial fibrillation (POAF).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective isolated on-pump CABG surgery
- •Informed consent
排除标准
- •Patients with a severe pulmonary disease
- •Patients with renal failure (GFR<30 mL/min/1.73 m2)
- •Patients with liver failure
- •Peripheral vascular disease affecting the upper limbs
- •Patients on sulfonylurea derivatives.
- •Patients with atrial fibrillation in their case history
- •Prior cardiac surgery (Re-operations)
结局指标
主要结局
Postoperative atrial fibrillation
时间窗: Up to 10 days after surgery
A patient will be classified as belonging to the postoperative atrial fibrillation group if they have any episode of atrial fibrillation, measured by telemetry, lasting more than 1 minute during their postoperative days at the hospital.
次要结局
- Length of hospital stay(Maximum 14 days)