Thyroid Nodule Gene Sequencing in a Danish Population - a Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Circulating tumor DNA
研究概览
简要总结
This pilot study aims at describing the prevalence and distribution of molecular alterations in thyroid nodules of benign and malignant origin at the level of DNA and RNA in a Danish population.
Patients with thyroid nodules suspected of malignancy is included prospectively.
Tissue samples are collected for molecular analyses form surgical specimens and bloodsamples, and preoperative clincial features are registered.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Thyroid nodule >1.5 cm
- •BSRTC: IV, V, og VI
排除标准
- •No surgical specimen available
- •Purely cystic nodules
结局指标
主要结局
Circulating tumor DNA
时间窗: Two years
Whole genome sequencing of leucocyt DNA and circularing DNA
DNA alterations
时间窗: Two years
Whole genome sequencing by next generation sequencing
DNA methylation
时间窗: Two years
Whole Genome Bisulfite Sequencing
RNA alterations
时间窗: Two years
Total RNA sequencing including circular RNA, micro RNA and messenger RNA
次要结局
未报告次要终点
研究者
Kristine Zøylner Rubeck
Principal investigator
Aarhus University Hospital