Sensorimotor Basis of Speech Motor Learning and Retention
概览
- 阶段
- 不适用
- 干预措施
- continuous theta-burst stimulation (cTBS)
- 疾病 / 适应症
- Speech
- 发起方
- Yale University
- 入组人数
- 330
- 试验地点
- 1
- 主要终点
- Speech motor learning
- 状态
- 招募中
- 最后更新
- 2个月前
概览
简要总结
The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well.
详细描述
Aim 1 involves tests of speech motor memory retention following disruption of left hemisphere brain activity in either auditory, somatosensory or motor cortex or to a control site (hand area motor cortex right hemisphere). Continuous theta-burst stimulation (cTBS) is delivered following adaptation to altered auditory feedback to assess its effects on the retention of new learning. Aim 2 assesses the temporal order in which plasticity occurs in cortical motor and sensory brain areas during speech motor learning. In Aim 3, resting-state fMRI will be interleaved with speech motor adaptation. For information specific to each aim, please refer to the below corresponding, separate, clinicaltrials.gov records: unique IDs: 2000037622\_a for Aim 1, 2000037622\_b for Aim 2 and 2000037622\_c for Aim 3.
研究者
入排标准
入选标准
- •Fluent English speakers
- •Right-handed
- •Normal hearing
- •No speech disorder or reading disability
排除标准
- •Cardiac pacemaker
- •Aneurysm clip
- •Heart or Vascular clip
- •Prosthetic valve
- •Metal implants
- •Metal in brain, skull, or spinal cord
- •Implanted neurostimulator
- •Medication infusion device
- •Cochlear implant or tinnitus (ringing in ears)
- •Personal and/or family history of epilepsy or other neurological disorders or history of head concussion
研究组 & 干预措施
Speech Motor Learning and Retention Aim 1
Aim 1: Participants will perform learning tasks while receiving altered/unaltered auditory feedback with cTBS applied to the appropriate area of the brain following learning. Retention of learning is assessed 24 hours later.
干预措施: continuous theta-burst stimulation (cTBS)
Speech Motor Learning and Retention Aim 1
Aim 1: Participants will perform learning tasks while receiving altered/unaltered auditory feedback with cTBS applied to the appropriate area of the brain following learning. Retention of learning is assessed 24 hours later.
干预措施: Adaptation
Speech Motor Learning and Retention Aim 2
Aim 2: Participants will perform learning tasks combined with shifted auditory feedback. Motor cortical excitability will be measured using single-pulse TMS to elicit motor evoked potentials.
干预措施: Adaptation
Speech Motor Learning and Retention Aim 2
Aim 2: Participants will perform learning tasks combined with shifted auditory feedback. Motor cortical excitability will be measured using single-pulse TMS to elicit motor evoked potentials.
干预措施: Single pulse Transcranial magnetic stimulation (TMS)
Speech Motor Learning and Retention Aim 3
Aim 3: Participants will have fMRI with behavioral measures of speech motor learning.
干预措施: Adaptation
Speech Motor Learning and Retention Aim 3
Aim 3: Participants will have fMRI with behavioral measures of speech motor learning.
干预措施: fMRI
结局指标
主要结局
Speech motor learning
时间窗: Performance as measured at the end of learning (30 minute session)
Audapter software will be used to alter the first and second formant frequencies of the spoken words and this is played back to subjects through headphones. Subjects will be tested both with unaltered feedback and with abruptly introduced frequency shifts.The change in the first (F1) and second format frequency (F2) values will be assessed using Praat.
Retention of learning
时间窗: 24 hours after learning (re-test lasts 30 minutes)
The retention of adaptation to altered auditory feedback (and relearning) will be quantified in terms of F1 and F2 frequency shifts (relative to pre-training baseline). Larger values indicate more complete relearning or retention.