Methodological Design for Evaluating the Immune Capacity of Bivalve Fluids From Anodonta Cygnea in SARS and COVID-19 Human Infection: Intelligent Medicine Integration.
试验速览
- 阶段
- 2 期
- 入组人数
- 45
- 试验地点
- 3
- 主要终点
- Immunologic system change
研究概览
简要总结
The present work proposes to find if a bio-active composite in the hemolymph or plasma of the freshwater bivalve Anodonta cygnea is able to offer immunity and specificity for meliorating the major symptoms in human SARS and COVID-19 lineage infection. The Methodology concerns in silico procedures using organic fluids from 54 bivalves (in very specific conditions) to evaluate their therapeutic effects in 6 voluntary SARS and COVID-19 infected persons with an integrative diagnosis by a computational Mora®Nova apparatus to access the basal and experimental human physiological parameters.
详细描述
A deep and consistent study will be developed with an increase in the human sampling for better understanding the intervention efficacy of this intelligence medicine integrator, the Mora® Nova method. These in silico experiments when associated with the bioresonance frequencies from stimulated hemolymph compounds of the freshwater bivalve A. cygnea, may lead us to expect high plasticity and immunological potential.
Obviously, additional in vitro studies in future, with adequate culture cell lineages in different conditions and with bioresonance treatment by Mora® Nova method, should also be accomplished with hemolymph/plasma interference to confirm the pertinence, and the real efficacy on SARS / COVID-19 infection as well as to clarify the respective biological mechanisms.
In addition, to analyze and evaluate any specific bioactive compound from the induced hemolymph condition needs molecular experiments which can give deep structural information concerning any efficient molecule against the SARS / COVID-19 virus lineage and respective mutants. Effectively, according to current scientific opinion, the virus mutation phenomenon leads to great and problematic difficulty for maintaining the collective and human global immunization. In this case, the present Mora methodology offers a very functional, dynamic, and efficient process when combined with a biological model, as the bivalve A. cygnea, with high plasticity and eventual molecular reconstructive adaptation. This Mora procedure can extend to other immune-depressive diseases namely cancer, rheumatoid arthritis, and neurodegenerative diseases combining with respective stimulated bivalve fluids. It suggests opening a promising future perspective when applied to large human sampling as well as with in vitro cellular assays.
In addition, to explore this research with in vitro cell cultures and to do the characterization and the effects from bio-compounds on similar diseases is our close objective.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 14 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects with normal physiological state or any kind of comorbidity
排除标准
- •Subjects in highly critical health state
结局指标
主要结局
Immunologic system change
时间窗: T4 - Day 3 - After adding the interface of virus incubated fluid during 48 hours
Voll Electromagnetic conductance reading (Hz) on immunologic system biopoints
Immunologic system
时间窗: T0 - Day 1 - Baseline
Voll Electromagnetic conductance reading (Hz) on immunologic system biopoints
Pulmonary system
时间窗: T0 - Day 1 - Baseline
Voll Electromagnetic conductance reading (Hz) on pulmonary system biopoints
Pulmonary system change
时间窗: T4 - Day 3 - After adding the interface of virus incubated fluid during 48 hours
Voll Electromagnetic conductance reading (Hz) on pulmonary system biopoints
Cardiac system
时间窗: T0 - Day 1 - Baseline
Voll Electromagnetic conductance reading (Hz) on cardiac system biopoints
Cardiac system change
时间窗: T4 - Day 3 - After adding the interface of virus incubated fluid during 48 hours
Voll Electromagnetic conductance reading (Hz) on cardiac system biopoints
次要结局
- Nervous system(T0 - Day 1 - Baseline)
- Gastrointestinal system(T0 - Day 1 - Baseline)
- Gastrointestinal system Change(T4 - Day 3 - After adding the interface of virus incubated fluid during 48 hours)
- Nervous system change(T4 - Day 3 - After adding the interface of virus incubated fluid during 48 hours)
- Endocrine system(T0 - Day 1 - Baseline)
- Endocrine system change(T4 - Day 3 - After adding the interface of virus incubated fluid during 48 hours)
研究者
Jorge Pereira Machado
Principal Investigator
Universidade do Porto