In Vivo Imaging of Corticotropin-releasing Factor - Nociceptin Receptor Interactions
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- [C-11]NOP-1A Volume of Distribution Expressed Relative to Total Plasma Concentration
研究概览
简要总结
To determine if [C-11]NOP-1A receptor binding (VT) can be altered by an intravenous hydrocortisone (cortisol) challenge through CRF-NOP interactions
详细描述
Examines changes in [C-11]NOP-1A pharmacokinetics caused by an intravenous hydrocortisone challenge (1 mg/kg)
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males or females between 18 and 40 years old
排除标准
- •Current DSM-5 psychiatric disorders
- •Binge drinking as defined in NIAAA criteria in the past month
- •Recreational abuse of opiates, sedative-hypnotics, cocaine, amphetamines, MDMA, and PCP, as well as cannabis use
- •Currently on any prescription medical or psychotropic medication;
- •Current or past severe medical, endocrine, cardiovascular, immunological or neurological illnesses
- •Currently pregnant or breast-feeding;
- •History of radioactivity exposure via prior nuclear medicine studies or occupational exposure in past twelve months
- •Metallic objects in the body that are contraindicated for MRI;
- •First-degree relative with psychosis or mood disorders
研究组 & 干预措施
[C-11]NOP-1A PET Scan conditions
Baseline condition and Post-hydrocortisone (1 mg/Kg, intravenous) condition
干预措施: Hydrocortisone (Drug)
[C-11]NOP-1A PET Scan conditions
Baseline condition and Post-hydrocortisone (1 mg/Kg, intravenous) condition
干预措施: [C-11]NOP-1A (Radiation)
结局指标
主要结局
[C-11]NOP-1A Volume of Distribution Expressed Relative to Total Plasma Concentration
时间窗: Baseline and 3.5 hours post-hydrocortisone
VT is the volume of distribution expressed relative to total plasma concentration. This is defined consistent with that reported in Consensus nomenclature for in vivo imaging of reversibly binding radioligands (Reference: J Cereb Blood Flow Metab 2007 Sep;27(9):1533-9. doi: 10.1038/sj.jcbfm.9600493)
次要结局
未报告次要终点
研究者
Rajesh Narendran
Visiting Professor in Radiology
University of Pittsburgh