NCT02303483已完成不适用
The Effect of Nicotinamide Ribose (NR) on Substrate Metabolism, Insulin Sensitivity, and Body Composition in Obese Men - a Randomized, Placebo Controlled Clinical Trial
Aarhus University Hospital2 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2016年1月4日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Insulin sensitivity
研究概览
简要总结
In animals, treatment with vitamin B3 improved insulin sensitivity and substrate metabolism. It is currently not know if vitamin B3 has the same positive effects in humans. In the current study the effect of a 3 month treatment with vitamin B3 on insulin sensitivity and substrate metabolism in obese men will be investigated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •written signed consent
- •BMI>30 kg/(m2)
- •age: 40-70
- •no medication
- •non-smoker
排除标准
- •endocrine disease
- •other severe disease
- •high daily activity level (>30 min / day)
结局指标
主要结局
Insulin sensitivity
时间窗: Change from baseline in insulin sensitivity at 3 months
determined by a hyperinsulineamic clamp
次要结局
- body composition(Change from baseline in body composition at 3 months)
- Activation of satellite cells(Change from baseline in activation of satellite cells at 3 months)
- insulin signalling in skeletal muscle and adipose tissue biopsies(Change from baseline in insulin signaling at 3 months)
- Substrate metabolism(Change from baseline in substrate metabolism at 3 months)
- glucose turnover(Change from baseline in glucose turnover at 3 months)
- Gut microbiota(Change from baseline in composition of gut microbiota at 3 months)
- Palmitate turnover(Change from baseline in palmitate turnover at 3 months)
- Incretin hormone secretion(Change from baseline in incretion hormone secretion at 3 months)
- lipid accumulation in liver and skeletal muscle tissue(Change from baseline in liver and muscle lipid content at 3 months)
研究者
Ole Dollerup
MD, PhD-student
Aarhus University Hospital
研究点 (2)
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