Investigation of the Regulation of Retinal and Choroidal Blood Vessels in Various Ocular Axes Lengths Based on Ultra-widefield Swept-source Optical Coherence Tomography Angiography Detection With Changes in Body Position
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 主要终点
- Retinal blood flow density
研究概览
简要总结
This prospective observational study aims to understand the effects of different subaxial body positions on choroidal and retinal blood vessel density. The main questions it aims to answer are as follows:1) How do retinal and choroidal blood vessels adjust and repair after changes in body position?2) Is the change of body position related to the factors that cause myopia？ 3) Are there any differences in the regulation ability of fundus blood vessels in people with different ocular axes under the condition of changes in body position?
详细描述
This project will use the wide field swept-source optical coherence tomography angiography, combined with data analysis and mining methods, to explore the self-adjustment and change mode and mechanism of retinal and choroidal blood vessels in the case of posture changes in an all-round and multi-angle way. There would be three kinds of postural changes, one is 15° head-up position, one is supine position, and the other is 15° head-down position. Relevant ophthalmological measurements would be performed before and after the postural changes. The objective is to discover the three-dimensional change mode of retinal and choroid blood vessels in different postures and compare the differences among people with different lengths of ocular axes, and to elucidate the relationship between the mode and ability of retinal and choroidal blood vessels to adjust and repair changes after changes in body position and myopia, to provide more ideas and objective basis for the occurrence and development of myopia, and lay a foundation for further research. It is of great significance to innovate the pathogenesis of myopia, deepen the theoretical understanding, and guide the prevention and control of myopia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 10 Years 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Corrected visual acuity ≥1.0 (international standard visual acuity chart);
- •Age 10-40 years old;
- •In good health;
- •Give informed consent and volunteer for the study. The process of obtaining informed consent complies with GCP regulations.
排除标准
- •Can not cooperate with the completion of relevant inspection and data collection;
- •Pregnant and lactating women;
- •Patients with amblyopia, glaucoma, retinitis pigmentosa, senile macular degeneration, retinal artery obstruction, retinal vein obstruction, diabetic retinopathy and other eye diseases that may affect the blood circulation and vascular diameter of the retina and vein, or those who have undergone intraocular surgery;
- •Patients with cardiovascular and cerebrovascular diseases, endocrine diseases, autoimmune diseases;
- •Long history of smoking and drinking;
- •History of ocular trauma;
- •The mentally ill;
- •Those who have taken drugs that affect blood circulation in the past 3 months;
结局指标
主要结局
Retinal blood flow density
时间窗: During the procedure
Two modes of SS-OCTA will be used for scanning, one is the wide-angle range of 24mm\*20mm grid for quantitative analysis of choroidal and retinal vascular density. The other is a scanning range of 12mm\*12mm mode, and the choroidal thickness, choroidal vascular volume ratio, and the area and perimeter of the macular avascular zone will be analysed.
Intraocular pressure
时间窗: During the procedure
iCare handheld contact tonometer wIll be used to measure the intraocular pressure of the subjects
Choroidal blood flow density
时间窗: During the procedure
Two modes of SS-OCTA will be used for scanning, one is the wide-angle range of 24mm\*20mm grid for quantitative analysis of choroidal and retinal vascular density. The other is a scanning range of 12mm\*12mm mode, and the choroidal thickness, choroidal vascular volume ratio, and the area and perimeter of the macular avascular zone will be analysed.
Choroidal thickness
时间窗: During the procedure
Two modes of SS-OCTA will be used for scanning, one is the wide-angle range of 24mm\*20mm grid for quantitative analysis of choroidal and retinal vascular density. The other is a scanning range of 12mm\*12mm mode, and the choroidal thickness, choroidal vascular volume ratio, and the area and perimeter of the macular avascular zone will be analysed.
Foveal avascular zone area
时间窗: During the procedure
Two modes of SS-OCTA will be used for scanning, one is the wide-angle range of 24mm\*20mm grid for quantitative analysis of choroidal and retinal vascular density. The other is a scanning range of 12mm\*12mm mode, and the choroidal thickness, choroidal vascular volume ratio, and the area and perimeter of the macular avascular zone will be analysed.
次要结局
- Axial length(Baseline, pre-procedure)