NCT03727399Enrolling By Invitation不适用
Identification of Allergen-reactive Antibodies in the Blood of Pollen Allergic Patients
Mabylon AG1 个研究点 分布在 1 个国家目标入组 300 人开始时间: 2018年10月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Antibody profiling
研究概览
简要总结
The project examines the hypothesis that monoclonal allergen-neutralizing antibodies can be recombinantly produced from B lymphocytes isolated from pollen allergic patients. Patient samples suitable for antibody cloning are selected based on seroprofiling for the respective allergens. The study aims at isolating lymphocytes from patients with potential allergen-neutralizing IgG in serum and to clone antibodies from antibody gene sequences obtained from B cells of those patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •History of allergic rhinitis, conjunctivitis or asthma due to sensitization to grass- or birch Allergens
- •Male or female patients older than 18 years
- •Written informed consent for providing blood and also to allow experimental manipulation
排除标准
- •Age < 18 years
- •Any corticosteroids within the last three days
- •Oral corticosteroid therapy within the last ten days
- •Parenteral depot corticosteroids within the last three months
结局指标
主要结局
Antibody profiling
时间窗: October 2018 - September 2021
Analysis and IgG profiling of specific antibodies binding major grass- and tree-pollen allergens in allergic patients.
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
Enrolling By Invitation
不适用
Identification of Anaphylactogenic Antibodies in Peanut AllergyPeanut AllergyNCT02821286University of Zurich100
已完成
不适用
Pilot Trial to Elaborate a Cutaneous Antigen Neutralization Test in Patients Suffering From RhinoconjunctivitisAllergyNCT00461721University of Zurich20
已完成
不适用
Antigen-Specific Cell Mediated Immune Response to Chlamydia TrachomatisChlamydiaNCT00970749University of Pittsburgh55
进行中（未招募）
不适用
Proof of concept study of combined allergen immunotherapy and antibiotics for the treatment of chronic atopic eczema - immunotherapy and antibiotics for atopic eczemaEUCTR2010-021284-33-GBResearch and Development Department, John Radcliffe Hospital
已完成
不适用
Immune Reactions in Contact Dermatitis Affected SkinAllergic Contact DermatitisNCT01546298Rockefeller University9