HLA B Leader in Patients With Psoriatic Arthritis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 658
- 试验地点
- 1
- 主要终点
- prevalence of HLA B leader in both groups
研究概览
简要总结
Psoriatic arthritis (PsA), a chronic immune-mediated heterogeneous inflammatory disease characterized by musculoskeletal inflammation (arthritis, enthesitis, spondylitis and dactylitis), usually occurs in patients with psoriasis. The spondyloarthritides (SPs) (of which psoriasis is one) are a group of inflammatory diseases that share an association with the HLA-B27 MHC class I molecule.
Given this association, these diseases are classically regarded as disorders of adaptive immunity.
In bone marrow donation, HLA-B exon 1 dimorphism (HLAB leader) is associated with risk of graft- versus-host disease, relapse and overall survival after unrelated hematopoietic cell transplantation (UHCT), haploidentical UHCT and cord transplantation. In the literature, there are no studies suggesting the involvement of the HLA B leader gene in MS and RPs. The main aim of this study is to compare the presence of the HLA B leader gene between a group of patients with psoriatic arthritis and a healthy group without inflammatory disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •For the "Patient" group:
- •Patient over 18 years of age
- •Patient affiliated to a social security scheme
- •Patient with psoriatic arthritis according to the CASPAR 2006 classification, followed at the CHU Amiens-Picardie.
- •For the "control" group:
- •Individuals over 18 years of age
- •Individual affiliated to a social security scheme
- •Individual having agreed to participate in the study
- •Individuals with no inflammatory or autoimmune diseases
排除标准
- •Patient or control not understanding French
- •Patient not included in the Amiens Picardie University Hospital's "Psoriatic Rheumatism" cohort, or control not included in the Amiens Picardie University Hospital's bone marrow donor cohort.
- •Patient or control objecting to participation in the study
结局指标
主要结局
prevalence of HLA B leader in both groups
时间窗: 1 year
prevalence of HLA B leader in patients with psoriatic rheumatism compared to the healthy group by autoimmune disease
次要结局
- Prevalence of HLAB27 gene in both groups(1 year)
- prevalence of the HLAB27/ HLA b Leader gene in different forms of psoriatic rheumatism patient group(1 year)