Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- CT and MR findings
研究概览
简要总结
In 2014 radiologic lesions were detected at one or more semicircular canals using CT and MR imaging of temporal bone in subjects carrying the p.P51S mutation in COCH. These lesions are believed to present at more advanced stages of the hearing and vestibular deterioration. Since then, other authors have described similar lesions in advanced non-genetic hearing and vestibular impairment as well.
The purpose of this study is therefore to assess the radiologic investigation using CT and MR imaging of temporal bone to all subjects presenting with bilateral vestibulopathy, using the Barany criteria, compared to the p.P51S population.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •must meet the Barany criteria for bilateral vestibulopathy: bilaterally pathological horizontal angu- lar VOR gain <0.6, measured by the video-HIT5 or scleral-coil technique and/or
- •reduced caloric response6 (sum of bither- mal max. peak SPV on each side <6◦/sec7) and/or
- •reduced horizontal angular VOR gain <0.1 upon sinusoidal stimulation on a rota- tory chair (0.1 Hz, Vmax = 50◦ /sec) and a phase lead >68 degrees (time constant <5 sec).
- •must be 18 or older
排除标准
- •does not meet Barany criteria for BV
- •contraindication for CT and MR imaging
结局指标
主要结局
CT and MR findings
时间窗: at time of recruitment
presence of focal sclerosis or signal loss on CT \& MR at one or more semicircular canals
genetic test
时间窗: at time of recruitment
p.P51S mutation in COCH gene
次要结局
- vestibular test 1(at time of recruitment)
- vestibular test 3(at time of recruitment)
- audiometry(at time of recruitment)
- vestibular test 2(at time of recruitment)
研究者
Sebastien Janssens de Varebeke
principal investigator
Jessa Hospital