Reproducibility of T Wave Alternans Testing in Patients With Ischemic Heart Disease.
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Reproducibility of TWA test results
研究概览
简要总结
Microvolt T-Wave Alternans (MTWA) is a relatively new non-invasive method for identifying patients at increased risk of sudden death from ventricular arrhythmias. MTWA can be measured during a routine exercise test, during pharmacologic stress or during cardiac pacing. Its clinical performance compares favorably with that of other non-invasive risk stratifiers and invasive electophysiologic studies. The purpose of the present study is to define the reproducibility of MTWA testing.
详细描述
The study will be performed in the Cardiac Rehabilitation Center at Assaf Harofeh Medical Center. Patients with coronary artery disease will be eligible to enroll.
Patient will undergo an exercise test on a stationary bicycle. TWA will be measured at heart rate of 105 and 115 BPM. The test will be repeated one week later in the same fashion. The patient will continue follow-up in the rehabilitation center as dictated by the rehabilitation program. Patients will be kept on their regular medications and there will be no change of the medications from the first TWA measurement to the second.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients enrolled in the cardiac rehabilitation center program
- •Patients with CAD
- •Age >18 and < 80 YO
- •Patients with a pacemaker or defibrillator with normal AV conduction
排除标准
- •Patients with chronic AF
- •Patients with multiple APB's or PVC's
- •Patients who are unable to increase their heart rate to 115 BPM and don't have a pacemaker.
- •Patients who are unable to exercise on a bicycle.
结局指标
主要结局
Reproducibility of TWA test results
时间窗: 1 week
次要结局
- Ventricular arrhythmias during exercise(1 week)