Myocardial Perfusion in Spontaneous Coronary Artery Dissection Using Stress Contrast Echocardiography
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Mayo Clinic
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Change in Microvascular Function
研究概览
简要总结
This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult >18 years old
- •Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history
排除标准
- •Unable to give consent
- •Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine.
- •Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®.
- •Pregnant.
- •Unable to interrupt breastfeeding.
- •Within 3 months of a heart attack.
- •Severe aortic stenosis.
- •Severe, uncontrolled hypertension (>200/110 mmHg at baseline).
研究组 & 干预措施
Spontaneous coronary artery dissection (SCAD)
Subject has a history of spontaneous coronary artery dissection (SCAD)
干预措施: Stress Echocardiography with Contrast (Procedure)
Healthy Subjects
Subjects are healthy with no significant medical history
干预措施: Stress Echocardiography with Contrast (Procedure)
结局指标
主要结局
Change in Microvascular Function
时间窗: Baseline, immediately after the Stress Echocardiography
Microvascular Function will be determined by Microvascular Blood Flow (Liters/Minute). Microvascular Blood Flow will be measured by a stress echocardiogram with contrast. A higher Microvascular Blood Flow indicated better blood flow circulation.
Change in Blood Pressure
时间窗: Baseline, immediately after the Stress Echocardiography
Change is blood pressure will be measured by a stress echocardiogram with contrast (mmHg).
Change in Heart Rate
时间窗: Baseline, immediately after the Stress Echocardiography
Change in heart rate will be measured by a stress echocardiogram with contrast (beats per minute).
次要结局
未报告次要终点
研究者
Marysia Tweet
Principal Investigator
Mayo Clinic