NCT00935233Unknown不适用
ICICLE- A Study to Investigate the genetiCs of In Situ Carcinoma of the ductaL subtypE
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 6,000
- 试验地点
- 18
- 主要终点
- Collection of blood and/or tumor tissue
研究概览
简要总结
RATIONALE: Studying genes in samples of blood and/or tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.
PURPOSE: This research study is looking at blood and/or tumor tissue samples from patients with ductal carcinoma in situ and blood samples from healthy volunteers.
详细描述
OBJECTIVES:
Primary
- To collect blood and/or tumor tissue of patients with ductal breast carcinoma in situ (DCIS) and their age- and ethnicity-matched controls to identify the inherited variation that predisposes women to develop DCIS.
- To determine the frequency of these variants.
- To determine the effect of these variants on tumor risk.
- To determine the benefit of testing for these variants in the clinical setting so that those at higher risk could be identified, counseled, and screened.
Secondary
- To analyze the acquired genetic changes within DCIS to identify which cases are more likely to develop invasive disease.
研究设计
- 研究类型
- Observational
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Collection of blood and/or tumor tissue
Frequency of genetic variants that predispose women to develop ductal carcinoma in situ (DCIS)
Effect of these variants on tumor risk
Benefit of testing for these variants
次要结局
- Analysis of acquired genetic changes within DCIS
研究者
研究点 (18)
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