Predictors of In-Hospital Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest: A Retrospective Observational Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 168
- 试验地点
- 2
- 主要终点
- In-Hospital Mortality
研究概览
简要总结
This retrospective observational cohort study aims to identify early predictors of short- and mid-term mortality in adult patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest. Eligible patients admitted to the intensive care unit between January 1, 2024 and May 31, 2025 were identified retrospectively from electronic medical records following institutional ethics approval. Clinical, biochemical, and resuscitation-related parameters recorded within the first 24 hours of ICU admission were analyzed. The primary objective was to determine factors independently associated with short-term mortality. Six-month mortality was additionally assessed using hospital records and the national death registry. The findings are expected to improve risk stratification and clinical decision-making in post-cardiac arrest care.
详细描述
This retrospective observational cohort study was conducted in the intensive care unit (ICU) of Gazi Yaşargil Training and Research Hospital, Turkey. Adult patients (≥18 years) who achieved return of spontaneous circulation (ROSC) after cardiac arrest and were admitted to the ICU between January 1, 2024 and May 31, 2025 were identified retrospectively from electronic medical records following institutional ethics approval.
Baseline demographic, clinical, laboratory, and resuscitation-related variables recorded within the first 24 hours of ICU admission were extracted from hospital records. These variables included arrest characteristics, time to ROSC, initial rhythm, hemodynamic parameters, neurological status, laboratory biomarkers, and therapeutic interventions routinely performed in ICU practice.
The primary outcome was 30-day all-cause mortality. Secondary outcomes included 24-hour, 7-day, and 6-month mortality, neurological outcome at hospital discharge, and ICU length of stay. Six-month mortality status was confirmed using hospital records and the national death registry.
A total of 168 eligible patients were identified during the study period. Multivariate logistic regression analysis was performed to identify independent predictors of mortality. No interventions beyond routine clinical care were conducted.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Achieved return of spontaneous circulation (ROSC) after cardiac arrest
- •Admitted to the intensive care unit (ICU)
- •Informed consent obtained from patient or legal representative (if applicable)
排除标准
- •Age < 18 years
- •Known pregnancy
- •Brain death at the time of ICU admission
- •Patients with missing key clinical or laboratory data
- •Declined participation or legal refusal
结局指标
主要结局
In-Hospital Mortality
时间窗: From ICU admission to hospital discharge (up to 60 days)
All-cause mortality recorded during the index hospital stay following return of spontaneous circulation (ROSC).
6-Month Mortality
时间窗: 6 months after ICU admission
All-cause mortality assessed at 6 months following the initial cardiac arrest event. Mortality status is confirmed through hospital records and national death registry.
次要结局
未报告次要终点
研究者
Ahmet Düzgün
Specialist in Internal Medicine and Intensive Care
Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital