Blood Flow Index as an Indicator of Successful Peripheral Nerve Block : A Prospective Observational Study Using Laser Speckle Contrast Imaging.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- diagnostic power of LSCI and pinprick sensory tests for predicting successful and failed blocks
研究概览
简要总结
Laser speckle contrast imaging (LSCI) allows real-time, non-invasive, quantitative measurements of regional blood flow. The aim of this prospective observational study was to evaluate the blood flow changes by LSCI after peripheral nerve block and determine whether this novel optical technique can be used as a reliable indicator of successful blocks.
详细描述
Methods: One hundred adult patients scheduled for elective upper or lower limb surgery with peripheral nerve block will receive LSCI measurements and pinprick sensory tests before the block and at 5-min intervals till 30 min after the block. The sensitivity, specificity of LSCI as a diagnostic method will be determined by receiver operator characteristic analysis.
Clinical Implications: LSCI with quantitative data could be used as an indicator of successful blocks.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •informed consent
- •American Society of Anesthesiologists physical statusⅠ-Ⅱ
- •Undergo elective upper or lower limb surgery with peripheral nerve block
排除标准
- •refusal to participate in the study
- •peripheral vascular disease
- •digit injury or deficiency
- •colored or infected fingernails/toenails
- •those who had taken vasodilatory drugs before surgery
- •preoperative analgesic medications
- •Any contraindications to peripheral nerve block such as coagulation abnormalities, allergy to local anaesthetics, peripheral neuropathy.
结局指标
主要结局
diagnostic power of LSCI and pinprick sensory tests for predicting successful and failed blocks
时间窗: at 5-min intervals till 30 min after regional block
sensitivity and specificity
次要结局
- blood flow index(5 min before regional block and at 5-min intervals till 30 min after regional block)
研究者
Wei Mei
Vice Director, Department of Anaesthesiology, Tongji Hospital of Tongji Medical College
Huazhong University of Science and Technology