NCT03405532暂停不适用
The Effect of the CPB on Kidney Blood Flow, Function and Oxygen Uptake During Open Heart Surgery in Patients With Diabetes Mellitus
Sahlgrenska University Hospital, Sweden1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2018年1月11日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Renal O2 extraction
研究概览
简要总结
Filtration of urine in the kidney requires sufficient oxygen supply. The filtration of urine is greater in patents with diabetes. Our theory is that the diabetic kidney has a higher oxygen demand than the non diabetic kidney thereby making the diabetic kidney more sensitive to decreased oxygen delivery following reduced blood flow. With a catheter inserted into the kidney vein we will monitor the blood flow and oxygen saturation before and during CPB, in patient with diabetes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with diabetes mellitus
- •Serum creatinine < 150 micromol/L preoperative
- •Heart surgery requiring CPB
- •LV (left ventricle) EF >40 %
- •Normal hemoglobin
排除标准
- 未提供
结局指标
主要结局
Renal O2 extraction
时间窗: 2 years
Renal O2 extraction measured by sampling blood from a catheter inserted into the kidney vein.
次要结局
- GFR(2 years)
- Renal blood flow(2 years)
研究者
Maria Tholén
Principal investigator
Sahlgrenska University Hospital, Sweden
研究点 (1)
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