The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage: a Randomized Control Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Change from baseline in maximal voluntary contraction
研究概览
简要总结
Strenuous exercise or exercise involving eccentric muscle contractions can lead to muscle damage and changes in muscle function; this is known as exercise-induced muscle damage (EIMD). It is known that brief, repeated periods of ischemia followed by reperfusion, known as Ischemic Preconditioning (IPC) cause a delay in cell injury in cardiac muscle as well as in various other organs.
Therefore the purpose of this study is to:
- Quantify the use of IPC in recovery following EIMD.
- Identify any effect of IPC during recovery on muscle function
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Physically Active Males
排除标准
- •Muscular skeletal disorders
研究组 & 干预措施
Ischemic Preconditioning
IPC (4 x 5 minute cycles @ 220 mmHg) with 5 min reperfusion between trials.
干预措施: Ischemic Preconditioning (Other)
Ischemic Preconditioning Placebo
Placebo (4 x 5 minute cycles @ 20mmHg) with 5 minutes between each cycle
干预措施: Ischemic Preconditioning (Other)
结局指标
主要结局
Change from baseline in maximal voluntary contraction
时间窗: pre exercise, 24 hours post, 48 hours post and 72 hours post exercise
Isometric MVC of the participants' dominant knee extensors was assessed using a strain gauge. MVCs were performed for 3 s with a 60 s rest between each repetition. The change in MVC will be determined 24, 48 and 72 hours following pre exercise conditions.
次要结局
- Change from baseline in Creatine kinase(pre exercise, 24 hours post, 48 hours post and 72 hours post exercise)
- Change from baseline in Limb girth(pre exercise, 24 hours post, 48 hours post and 72 hours post exercise)
- Change from baseline in Muscle soreness(pre exercise, 24 hours post, 48 hours post and 72 hours post exercise)
- Chnage from baseline in Vertical jump(pre exercise, 24 hours post, 48 hours post and 72 hours post exercise)
研究者
Stephen Patterson
Senior Lecturer Exercise Physiology
St Mary's University College