A Prospective Study About the Sensitization Patterns to Insects as Food Source in Patients With House Dust Mite Allergy Based on Clinical History, Skin Prick Tests and in Vitro Tests
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- Presence/absence of insect sensitization among seafood/Tropomyosin-sensitized patients versus patients with house dust mite sensitization alone
研究概览
简要总结
Patients allergic to seafood and/or sensitized to Tropomyosin of Skin Prick tests SPT or crustacean origin will may be also be sensitized to edible insects. Aim of the study is to evaluate whether patients allergic to seafood and/or sensitized to Tropomyosin of SPT or crustacean origin may be more often be sensitized to edible insects used as food source.
详细描述
House dust mite allergy is a common problem in Europe. In addition to inhalant allergies sensitization to mites can be related to food allergy namely seafood. Insects are also widespread food sources in many regions of the world.
In this study skin testing and laboratory tests are planned in patients with known house dust mite allergy to evaluate a possible sensitization to insects. Patients must also complete a questionnaire. A drug therapy or other intervention is not planned.
Aim of the study is to evaluate whether patients allergic to seafood and/or sensitized to Tropomyosin of SPT or crustacean origin may be more often be sensitized to edible insects used as food source.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: 18 < x < 70
- •House dust mite sensitization with or without sensitization to seafood
- •Subject is capable of giving informed consent
- •Signed informed consent
排除标准
- •Use of antihistamines, systemic corticosteroids during testing and within three days (antihistamines) or two weeks (corticosteroids) prior to testing
- •Use of immunosuppressive agents
- •History of cancer except for treated basal cell or spinal cell carcinoma of the skin
- •Active or recurrent bacterial, fungal or viral infection at the time of enrollment, including patients with evidence of Human Immunodeficiency Virus (HIV) infection, Hepatitis B and Hepatitis C infection, active or untreated latent tuberculosis.
- •Female patients of childbearing potential who are pregnant or breast feeding or planning a pregnancy during the duration of the trial and/or not practicing acceptable birth control for the duration of the trial
- •Known or suspected non-compliance, drug or alcohol abuse,
- •Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant,
- •Previous enrollment into the current study,
- •Enrollment of the investigator, his/her family members, employees and other dependent persons,
研究组 & 干预措施
All Patients
It is a single arm study. Skin prick testing and laboratory Tests are carried out on all patients in the same way
干预措施: Skin prick test (Other)
结局指标
主要结局
Presence/absence of insect sensitization among seafood/Tropomyosin-sensitized patients versus patients with house dust mite sensitization alone
时间窗: 1 week
Sensitization (+/-)
次要结局
- Sensitization pattern in seafood sensitizes patients in comparison between insect-sensitized versus non-insect-sensitized patients(1 week)
- Sensitization pattern in insect sensitized patients in comparison between resident and immigrant populations in Switzerland(1 week)
- Sensitization pattern in seafood sensitized patients in comparison between resident and immigrant populations in Switzerland(1 week)
- Description of possible cross reactions between seafood and insect allergens(1 week)
- Sensitization pattern in insect sensitized patients in comparison between seafood-sensitized versus non-seafood-sensitized patients(1 week)
- Frequency of sensitization to the various insect allergens(1 week)