The Impact of Modifications on Respiratory Management of Preterm Infants on the Death or Bronchopulmonary Dysplasia Outcome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- BRONCHOPULMONARY DySPLASIA
研究概览
简要总结
This observational study evaluates the impact of respiratory management modifications implemented in our institution on the intubation rates and the death or Bronchopulmonary Dysplasia (BPD) outcome.
详细描述
Less invasive respiratory management has been implemented in most neonatal units as well as lung protective ventilatory strategies when intubation is required in order to minimize ventilator induced lung injury.
In our institution a new ventilatory protocol including less invasive surfactant administration, Synchronized nasal positive pressure ventilation and early rescue High frequency ventilation has been implemented during 2013-14.
Hypothesis
New less invasive and lung protective strategies to prevent lung injury had been effective in reducing intubation rates.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 36 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All preterm Infants born with less than 32wGA admitted in our NICU.
排除标准
- •Congenital malformations and Known Chromosomal disorders,
结局指标
主要结局
BRONCHOPULMONARY DySPLASIA
时间窗: 36 weeks of postmenstrual age.
Diagnosis of moderate-severe bronchopulmonary dysplasia (physiological definition)
mortality
时间窗: before discharge
death
次要结局
- Mechanical ventilation(during hospitalization)
研究者
Manuel Sanchez Luna
Head of Neonatology, Clinical Professor
Hospital General Universitario Gregorio Marañon