NCT01583803Unknown不适用
Investigation of the Sex Differences in Oral Microbiota and Their Effect on Circulating Nitrite Levels
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Bacterial species identification
研究概览
简要总结
Females have a lower incidence of hypertensive and cardiovascular disorders that may relate to differences in nitrogen oxides in the blood and saliva. Some nitrogen oxides are recycled with the help of oral bacteria to nitric oxide which is protective against vascular disorders. This study will test the hypothesis that females have different numbers and species of these nitrogen-oxide reducing bacteria.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects aged 18-45 who have volunteered themselves and are willing to sign the consent form
排除标准
- •Healthy subjects unwilling to consent
- •History of hypertension, diabetes or hypertensive on BP measurement
- •Pregnant, or any possibility that a subject may be pregnant unless in the latter case a pregnancy test is performed with a negative result
- •History of any serious illnesses, including recent infections or trauma
- •Subjects taking systemic medication (other than the oral contraceptive pill)
- •Subjects with self-reported use of mouthwash or tongue scrapes
- •Subjects with recent or current antibiotic use (within 3 months)
- •Subjects with a history, or recent treatment of (within last 3 months) of any oral condition (excluding caries), including gingivitis, periodontitis and halitosis
结局指标
主要结局
Bacterial species identification
时间窗: At baseline
次要结局
- Bacterial count(At baseline)
- Blood pressure(At baseline)
- Nitrogen oxide levels in biological fluids(At baseline)
- Oral nitrate reduction(At baseline)
研究者
Amrita Ahluwalia
Professor of Vascular Pharmacology
Queen Mary University of London
研究点 (1)
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