Effect of Follicular Flushing on the Ongoing Pregnancy Rate in Patients Who Developed Four or Fewer Follicles of 14mm Following Standard Ovarian Stimulation for In-vitro Fertilization Treatment - A Randomized Controlled Trial.
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 4
- 试验地点
- 1
- 主要终点
- ongoing pregnancy rate
研究概览
简要总结
The aim of the present study is to determine the effect of follicular flushing on the ongoing pregnancy rate in patients who developed four or fewer follicles of 14mm following standard ovarian stimulation for IVF.
详细描述
Oocyte aspiration under the guidance of transvaginal ultrasound is an integral part in IVF treatment. Follicular flushing has been advocated. However, subsequent data from randomized trials failed to demonstrate any benefits with routine follicular flushing in normally responding patients. Instead, it has been shown to prolong the operating time, increase the procedure-related pain and analgesics requirement. Most of the IVF centers no longer perform routine follicular flushing in normally responding patients.
The potential role of follicular flushing in patients with a limited number of developing follicles is conflicting based on the recently published randomized trials. The aim of the present study is to determine the effect of follicular flushing on the ongoing pregnancy rate in patients who developed four or fewer follicles of 14mm following standard ovarian stimulation for IVF.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- — 至 42 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age of women <43 years
- •Normal uterine cavity on saline sonogram
- •Endometrial thickness >=8mm on the day of hCG
排除标准
- •Planned not to have fresh embryo transfer
- •Cycle cancelled prior to hCG administration
- •Natural cycle IVF
- •Presence of hydrosalpinges on scanning which are not surgically treated
- •Presence of endometrial polyps on scanning
- •Undergoing preimplantation genetic diagnosis
结局指标
主要结局
ongoing pregnancy rate
时间窗: 10 weeks of gestation
次要结局
- number of oocytes retrieved(on the day of retrieval)
- number of embryo available for transfer(on the day of embryo transfer)
- operation time of the retrieval(on the day of retrieval)
- clinical pregnancy rate(6 weeks of gestation)
- pain score of retrieval(on the day of retrieval)
研究者
Professor Ernest Hung-Yu Ng
Professor
The University of Hong Kong