Inter-Individual Difference in Postprandial Response to Uniform Diet Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 150
- 试验地点
- 1
研究概览
简要总结
Background
People show large differences in blood glucose after eating the same food. This variation is influenced by genetics, microbiome, lifestyle, and body composition. Most research is Western; Indian diets and Ayurvedic concepts like Prakriti may affect responses differently.
Hypothesis
Postprandial glucose responses vary widely between individuals and are influenced by microbiome, Prakriti, Agni, and host factors.
Aim
To measure inter-individual variation in post-meal glucose responses in an Indian population and relate it to microbiome and Prakriti.
Objectives
Assess glucose responses to standardized meals.
Correlate responses with microbiome and Ayurvedic parameters.
Methodology (Very Short)
Single-arm study (150 adults, 18–50 years). Participants undergo 14 days of CGM, seven standardized test meals, OGTT, blood sampling (glucose, insulin, TG, biomarkers), Prakriti assessment, and stool microbiome analysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •BMI between 18 and 25 HbA1c less than 5.7 Hb level more than 12 and 13 for males and females respectively.
排除标准
- •Allergic to planned meal (paratha and curd).
- •Any volunteer claiming to be diagnosed with any non-communicable diseases / chronic illness or auto immune disorders Unable to fast from 9 pm until 9 am on the clinic day.
- •Use of PPIs (such as omeprazole and pantoprazole) in the last two weeks Use of antibiotics in the last one month Pregnancy and lactation Unable to wear the CGM (Continuous Glucose Monitoring Device) on their arm during the study, e.g. because their profession prohibits it at work.
研究者
Dr Sanketh V Sharma
The University of Trans-Disciplinary Health Sciences and Technology