NCT00727948已完成早期 1 期
The Impact of the Anti-Platelet Agent Aspirin on Angiogenesis Proteins in Women With Breast Cancer
适应症
干预措施
相关药物
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- Changes in pro-angiogenic and anti-angiogenic protein levels.
研究概览
简要总结
Changes in major angiogenic proteins have been seen following initiation of tamoxifen and aromatase inhibitor therapy in women with breast cancer. One source of these proteins is the circulating platelet pool. The investigators hypothesize that in addition to their anti-platelet properties, agents such as aspirin can be used as targeted anti-angiogenesis therapy. The investigators will determine the influence of aspirin on the release of angiogenic proteins from platelets in 35 patients with breast cancer.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 95 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Histologically or cytologically proven breast cancer
- •Pre or post-menopausal
- •Completed adjuvant non-hormonal therapy >30 days prior to initiation of study (surgery and/or chemotherapy and/or radiation therapy)
- •Platelet count and hemoglobin within normal ranges for local lab within 30 days of initiation of study therapy
- •Receiving tamoxifen therapy for at least 90 days prior to initiation of study therapy, and is expected to continue that therapy for the duration of the study (75 days)
排除标准
- •Chemotherapy, radiation therapy or surgery within 30 days of study therapy
- •Current use of aspirin, anti-platelet or anti-coagulation agents on a continuous basis
- •Prior history of gastrointestinal or central nervous system bleeding, or documented or self-reported blood in stools or bright red blood per rectum
研究组 & 干预措施
receive aspirin
Experimental
干预措施: Aspirin (Drug)
结局指标
主要结局
Changes in pro-angiogenic and anti-angiogenic protein levels.
时间窗: 75 days
次要结局
未报告次要终点
研究者
Chris Holmes
Associate Professor of Medicine
University of Vermont
研究点 (1)
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