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临床试验/NCT05912023
NCT05912023进行中(未招募)不适用

Vaping Associated Perioperative Pulmonary Complications - Anesthetic Implications

Navy Medical Center San Diego1 个研究点 分布在 1 个国家目标入组 300 人开始时间: 2023年7月28日最近更新:
适应症

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
300
试验地点
1
主要终点
Perioperative pulmonary complications

研究概览

简要总结

Prospective observational study evaluating the incidence, and qualifying the types, of perioperative pulmonary complications in patients that vape.

详细描述

The primary objective of our study is to determine the rate at which patients that vape or use e-cigarettes experience perioperative pulmonary complications during and following general anesthesia. Complications of interest will include postoperative atelectasis with hypoxemia necessitating oxygen therapy, pneumothorax, pneumonia, bronchospasm, bronchospasm requiring bronchodilator therapy, exacerbation of underlying pulmonary disease, pneumonia, ARDS, and acute respiratory failure. Hospital course, including prolonged PACU stay, prolonged hospital admission for inpatients, and rate of ICU admissions, will also be investigated.

A secondary objective will be to further investigate and include the relationship between vaping cessation timeline in the preoperative period and the occurrence of PPCs, which is similarly underreported in the literature. Furthermore, the study will assess how effectively anesthesia providers are screening for vaping or e-cigarette use as part of the preoperative evaluation, given that "it is unclear whether anesthesiologists and surgeons routinely ask patients explicitly about vaping" in the pre-operative setting. This lack of representative screening for vaping further obscures an understanding of the relationship between vaping, vaping cessation, and PPCs.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
12 Years 至 80 Years(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Surgical Patient
  • General Anesthesia
  • Hx of vaping

排除标准

  • Pregnancy
  • Active preoperative pulmonary infection
  • Recent pulmonary infection (within 8 weeks)
  • Active tobacco smoker
  • Poorly controlled reactive airway disease (requires more than PRN albuterol)
  • Non-Lung Protective Ventilation

结局指标

主要结局

Perioperative pulmonary complications

时间窗: From the initiation of general anesthesia through postoperative day seven.

Complications of interest will include postoperative atelectasis with hypoxemia necessitating oxygen therapy, pneumothorax, pneumonia, bronchospasm, bronchospasm requiring bronchodilator therapy, exacerbation of underlying pulmonary disease, pneumonia, ARDS, and acute respiratory failure. Hospital course, including prolonged PACU stay, prolonged hospital admission for inpatients, and rate of ICU admissions, will also be investigated.

次要结局

  • Vaping cessation timeline(From the initiation of general anesthesia through postoperative day seven.)

研究者

申办方类型
Fed
责任方
Sponsor

研究点 (1)

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