NCT02892526Unknown不适用
Wound Vitality Markers in Forensic Pathology
Central Hospital, Nancy, France1 个研究点 分布在 1 个国家目标入组 57 人开始时间: 2014年12月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 57
- 试验地点
- 1
- 主要终点
- Specificity of markers for vitality diagnosis
研究概览
简要总结
The purpose is to determine intrinsic properties of various immunohistochemical markers (FVIIIra, CD15, CD30, tryptase, TNFα, IL-1β, TGFα et TGFβ1) for diagnosis of vital wound, alone and in association (evaluation of sensibility with surgery wounds and evaluation of specificity with post-mortem wounds).
Secondary purposes are to measure the minimum time to obtain a positive labeling in vital wounds, and to evaluate inter-observer reproducibility of vitality diagnosis with different markers. Expression of microRNA miR 9, miR 21 et miR 198 will be also studied.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Alive persons:
- •Abdominoplasty
- •Deceased persons:
- •Medico-scientific autopsy for diagnosis
排除标准
- •Alive persons:
- •Fragmented sample with non-visible banks
- •Cutaneous pathology
- •Deceased persons:
- •Persons under protection
- •Medico-legal obstacle
- •Cutaneous pathology
结局指标
主要结局
Specificity of markers for vitality diagnosis
时间窗: baseline
Sensibility of markers for vitality diagnosis
时间窗: baseline
次要结局
- Expression level of miR 21 by qRT-PCR(baseline)
- Expression level of miR 9 by qRT-PCR(baseline)
- Expression level of miR 198 by qRT-PCR(baseline)
- Minimum time to obtain a labeling (between incision and devascularization)(baseline)
- Coefficient of inter-observer correlation of vitality diagnosis (for reproducibility analysis)(baseline)
研究者
研究点 (1)
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