The Prevalence and Associated Factors of Early Neurological Deterioration After Successful Recanalization Treatment in Patients With Acute Ischemic Stroke
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 主要终点
- Prevalence of early neurological deterioration after successful recanalization treatment in patients with acute ischemic stroke
研究概览
简要总结
stroke is a leading cause of morbidity and mortality worldwide. More than half (54.5%) of the 56.9 million deaths worldwide in 2106 were due to the top 10 causes.
Ischemic heart disease and stroke are the world's biggest killers, accounting for a combined 15.2 million deaths in 2106. These diseases have remained the leading causes of death globally in the last 15 years.
Recent clinical trials have shown that endo-vascular thrombectomy is an effective and safe recanalization modality for acute ischemic stroke patients .
Meta-analysis results show that endovascular treatment is associated with a high ratio of successful recanalization rate and a low rate of symptomatic hemorrhage .
Approximately 2.2-37.5% of patients with acute ischemic stroke might encounter early neurological deterioration (END).
Definition of END: An increase in NIHSS ≥4 or an increase in Ia of NIHSS ≥1 within 72 h after recanalization treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ischemic stroke of both sex.
- •More than 08 years.
- •Accepting all study requirements.
- •within time window for thrombolysis or thrombectomy
- •fulfilling criteria for thrombolysis or thrombectomy
排除标准
- •(A)Absolute Contraindications :
- •Intracerebral hemorrhage history or presence on imaging
- •Time of onset more than 465 hours
- •Blood pressure greater than 085/000 mm Hg
- •Recent severe head trauma or neurosurgical intervention
- •Coagulopathy (INR >067, thrombocytopenia, recent use of heparin or direct oral anticoagulants)
- •Endocarditis (infective)
- •Aortic dissection (B)Potential Contraindications :
- •1.Seizure at onset 2.Noncompressible arterial puncture 3.Recent surgery 4.Gastrointestinal or genitourinary bleeding 5.Multiple cortical microbleeds (>00)
- •Large intracranial aneurysms or arteriovenous malformations 7.Recent transmural myocardial infarction
- •Small NIHSS with nondisabling stroke symptoms
结局指标
主要结局
Prevalence of early neurological deterioration after successful recanalization treatment in patients with acute ischemic stroke
时间窗: 1 year
Prevalence of early neurological deterioration after successful recanalization treatment in patients with acute ischemic stroke
factors of deterioration
时间窗: 1 year
factors of deterioration
次要结局
未报告次要终点
研究者
Osama Ibrahim Aboelfath Ibrahim
osama ibrahim abo-elfath
Assiut University