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临床试验/NCT02503995
NCT02503995已完成不适用

Influence of Regular Antenatal Physical Exercise on Cardiovascular, Haemodynamic and Autonomic Nervous System (CHANS) Function During and After Pregnancy

Swansea University0 个研究点目标入组 90 人开始时间: 2012年3月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
90
主要终点
Cardiac Stroke Volume - Time Point 4

研究概览

简要总结

This study aimed to investigate whether there are measurable differences in CHANS function in pregnant women who receive only standard antenatal care compared with those who additionally undertake a programme of regular physical exercise.

详细描述

The health benefits of physical exercise in the non-pregnant population are generally appreciated but its influence during pregnancy has not been clearly demonstrated. The focus of this proposal is to obtain for the first time a comprehensive understanding of the influence of regular physical exercise during pregnancy on cardiovascular, haemodynamic and autonomic nervous system (CHANS) parameters during pregnancy and following childbirth. This will involve assessing heart rate variability and cardiac stroke volume. This study will allow the investigators to compare CHANS parameters in pregnant women who are randomly assigned into three groups: a 'standard care' group and two groups who engage in a supervised programme of physical exercise (either land-based or water-based). The investigators will assess CHANS parameters at three stages during pregnancy and on one occasion following childbirth. This will allow the influence of regular (weekly) physical exercise on CHANS physiology to be assessed during advancing gestation. The investigators will thus use this study to provide initial evidence of the health benefits of regular and specific forms of antenatal physical exercise.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 45 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • Eligible participants were apparently healthy pregnant women aged 18 years or over, with no existing complications of pregnancy at their 12-week dating scan.

排除标准

  • Exclusion criteria were: a history of cardiovascular or chronic respiratory problems, sleep apnoea, or central/peripheral nervous system disorder.

结局指标

主要结局

Cardiac Stroke Volume - Time Point 4

时间窗: 12 weeks post-birth

Determined from thoracic impedance cardiogram, assessed as absolute value

Heart Rate Variability - Time Point 3

时间窗: 34-36 weeks gestation

Determined from 3-lead ECG, assessed as absolute value

Heart Rate Variability - Time Point 4

时间窗: 12 weeks post-birth

Determined from 3-lead ECG, assessed as absolute value

Heart Rate Variability - Time Point 1

时间窗: 10-12 weeks gestation

Determined from 3-lead ECG, assessed as absolute value

Cardiac Stroke Volume - Time Point 1

时间窗: 10-12 weeks gestation

Determined from thoracic impedance cardiogram, assessed as absolute value

Heart Rate Variability - Time Point 2

时间窗: 24-28 weeks gestation

Determined from 3-lead ECG, assessed as absolute value

Cardiac Stroke Volume - Time Point 2

时间窗: 24-28 weeks gestation

Determined from thoracic impedance cardiogram, assessed as absolute value

Cardiac Stroke Volume - Time Point 3

时间窗: 34-36 weeks gestation

Determined from thoracic impedance cardiogram, assessed as absolute value

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Dr Michael Lewis

Associate Professor

Swansea University

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