Gastric emptying and incretin hormones in idiopathic reactive hypoglycaemia following a mashed potato meal

The University of Adelaide0 个研究点目标入组 40 人开始时间: 2021年12月14日最近更新: 2022年12月5日

适应症

试验速览

暂无简介。

•Male and female aged 18 – 70 years, who have been diagnosed with idiopathic reactive hypoglycaemia by a primary care physician or endocrinologist
•For the control group:
•Male and female aged 18 - 70 years who do not have any hypoglycaemic disorder

•History of type 1 or type 2 diabetes
•Use of any medication that may influence gastrointestinal motor function, glycaemia, body weight or appetite (e.g. glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase 4 inhibitors, opiates, levodopa, clonidine, nitrates, phosphodiesterase type 5 inhibitors, sumatriptan, metoclopramide, domperidone, prucalopride or erythromycin)
•Evidence of drug abuse, consumption of more than 20 g alcohol per day or an active smoking history
•History of chronic gastrointestinal disease (inflammatory bowel disease, coeliac disease) or prior gastrointestinal surgery (other than uncomplicated appendicectomy or cholecystectomy)
•History of epilepsy
•History of severe respiratory, cardiovascular, hepatic and/or renal disease
•Impaired renal (as assessed by calculated creatinine clearance < 90 mL/min, iron status, or liver function tests outside the following ranges:
•-Alanine aminotransferase (ALT) >2x ULN
•-Aspartate transaminase (AST) >2x ULN
•-Alkaline phosphatase (ALP) >2x ULN
•-Bilirubin >24 mmol/L
•-Ferritin <15 ng/mL (Females), <30 ng/mL (Males)
•-Haemoglobin <115 g/L (Females), <130 g/L (Males)
•Donation of blood within the previous 3 months
•Participation in any other research studies within the previous 3 months that requires blood sampling or exposure to radiation
•Inability to give informed consent
•Female participants who are pregnant or planning for pregnancy, or are lactating

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