High-field (7T) MRI biomarkers for neurocognitive impairment in MELAS and the role of diabetes. - 7T MRI in MELAS

niversiteit Maastricht0 个研究点目标入组 52 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•Subjects aged 18 to 45 and subjects gave written informed consent.;MELAS patients:
•Confirmed carrier of the m.3243A>G mutation and mild MELAS phenotype (fatique, myopathy, mild exercise intolerance).;Diabetes type 2:
•Fasting blood glucose >= 7.0 mmol/l and/or used oral glucose-lowering medication or insulin.;Age, gender and level of education matched controls:
•Those that do not carry the m.3243A>G, the age, gender and level of eduction of the group of healthy controls should not differ significantly from the age of the group of patients

•All groups:
•Contra-indications for MRI examination: 1) pacemaker, 2) neurostimulator, 3) medication pump, 4) cochlear or hearing implant, 5) tattoos or other items that cannot be removed and include metal parts, 6) metal splinter in the eye, 7) pregnancy, 8) claustrophobia, 9) brain vessel clamps, 10) denture, which contains magnets, 11) operations in the past, where metal or synthetic material is used and still were in the body; psychiatric or other disorders likely to impact on informed consent; diabetes mellitus type 1 (DM1).;MELAS patients:
•Other mitochondrial/neurological/psychiatric disease/syndrome other than MELAS. Severe phenotype (stroke-like lesions and severe exercise intolerance).;Age, gender and level of eduction matched controls:
•Any mitochondrial/neurological/psychiatric disease/syndrome.

发起方