NL-OMON37694
Recruiting
Not Applicable
Functional MRI biomarkers of cognitive decrements in diabetes - Functional MRI in DM2
Medisch Universitair Ziekenhuis Maastricht0 sites132 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- brain function
- Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Enrollment
- 132
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •subjects aged 40\-75 years, subjects enrolled in the existing 'Maastricht Study', Subjects gave written consent to be approached for additional research, subjects belong to the 20% of the worst and 20% of the best performing (as based on neuropsychological cognitive testing) individuals.;Diabetes type 2:
- •fasting blood glucose \>\= 7\.0 mmol/l, after an oral glucose tolerance test (OGTT) blood glucose \>\= 11\.1 mmol/l or used oral glucose\-lowering medication or insulin.;Metabolic Syndrome:
- •Participants should meet three out of 5 of the following criteria:
- •1\. Waist circumference \> 88 cm (women), \> 102 cm (men)
- •2\. Triglycerides \>\= 1\.7 mmol/l
- •3\. HDL cholesterol \< 1\.3 mmol/l (women), \< 1\.0 mmol/l (men)
- •4\. Blood pressure \>\= 130/85 mmHg (or medication)
- •5\. Fasting blood glucose \>\= 6\.1 mmol/l, after an OGTT blood glucose \>\= 7\.8 mmol/l;Healthy controls:
- •Who fulfilled no more that 1 criterium of the metabolic syndrome, no Diabetes type 2\.
Exclusion Criteria
- •Contra\-indications for MRI examination:
- •1\) pacemaker, 2\) neurostimulator, 3\) medication pump, 4\) cochlear or hearing implant, 5\) tattoos or other items that cannot be removed and include metal parts, 6\) metal splinter in the eye, 7\) pregnancy, 8\) claustrophobia, 9\) brain vessel clamps, 10\) denture, which contains magnets, 11\) operations in the past, where metal or synthetic material is used and still were in the body ;Psychiatric comorbidity and inability to perform the functional MRI tests.
- •Diabetes mellitus type 1 (DM1\)
- •Subjects who are not belonging to the 20% of the worst and 20% of the best performing individuals
- •Last visit of the subjects to the M\-Study should be less than one year
Outcomes
Primary Outcomes
Not specified
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