Correlation Between Cognitive Functions and MRI in Multiple Sclerosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- Sheba Medical Center
- Enrollment
- 100
- Locations
- 1
- Last Updated
- 18 years ago
Overview
Brief Summary
The purpose of this study is to determine whether there is a correlation between cognitive functions and volume of specific brain area measured in MRI of multiple sclerosis patients.
Detailed Description
Recent literature suggests that multiple sclerosis is accompanied by significant deficits in cognitive performance. The origin of these cognitive deficits is not known, since the severity of cognitive deficits was not found to be correlated with disease parameters such as duration, lesion load or disease intensity as measured on standard scales (e.g. EDSS). The research hypothesis we plan to test is that the individual intensity of cognitive deficits is correlated with degeneration of specific neuronal structures related to cognitive performance, such as the hippocampus and prefrontal cortex. To test this hypothesis, we plan to perform volumetric measurements of such regions on MRI scans obtained from MS patients during the course of their clinical evaluation, and attempt to correlate those with the results of neuropsychological tests performed by the same subjects around the time of MRI scanning.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of Multiple Sclerosis
- •Age 18-65
Exclusion Criteria
- •Another brain disease
- •Brain trauma
- •Neurosurgery
Outcomes
Primary Outcomes
Not specified