The Relationship Between Cognitive Function and Functional Capacity, Cognitive Reserve, Reaction Time in Patients With Multiple Sclerosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- Inonu University
- Enrollment
- 76
- Locations
- 1
- Primary Endpoint
- Functional capacity assessment
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The aim of the study is to investigate the relationship between cognitive function, functional capacity, cognitive reserve and reaction time in patients with multiple sclerosis.
Detailed Description
Cognitive impairment in patients with MS is a common problem that significantly affects quality of life. It shows an association between functional capacity and physical fitness levels and cognition in non-MS populations, and especially in the elderly. Although cognitive dysfunctions are known, few studies have been found on its relationship with secondary problems caused by the disease and its correlation with other symptoms.
Investigators
Burcu Talu
Associate professor
Inonu University
Eligibility Criteria
Inclusion Criteria
- •Relapsing-remitting MS diagnosis
- •Expanded Disability Status Scale score \<5.5
- •Being able to use a smart phone
- •No relapse during the last 30 days
- •Being between the ages of 18-65
- •Mini-Mental State Examination score\>24
Exclusion Criteria
- •Severe Visual Impairment
- •Severe Psychiatric Disorder,
- •Severe Arthritis in Knee or Hip,
- •Pregnancy and other neurological or vestibular disorders that may prevent the patient from completing the functional examination
Outcomes
Primary Outcomes
Functional capacity assessment
Time Frame: baseline
The STS-5 test, on the other hand, requires patients to perform five sit-stand cycles in a standard chair (0.43-m high and 0.45-m wide) as quickly as possible, measured in seconds, and is used as an indicator of lower extremity muscle strength.
Cognitive Reserve Index Questionnaire
Time Frame: Baseline
A tool used to quantify, in a standardized model, cognitive reserve through an interview to the participant or to the caregiver. The questionnaire collects demographic information regarding the school curriculum, work and type of free-time activities. These three different indices (CRI-School, CRI-Work and CRI-Free Time) are then combined into a single "Index of Cognitive Reserve".
Cognitive function
Time Frame: Baseline
A mobile application called Trail Making Test was used to evaluate visual attention and cognitive flexibility. The completion time of subsections A and B was recorded. Working memory will be evaluated using a mobile application called Digit Span test. This application gives your maximum digit memory. This score has been saved.
Visiospatial perception
Time Frame: Baseline
The visuospatial perception was evaluated with the help of the mobile application called Corsi Block Tapping test. The highest span in this application is recorded.
Secondary Outcomes
- Nottingham Health Profile.(Baseline)
- Beck Depression Inventory(Baseline)
- Hand grip strength(Baseline)
- Fatigue Severity Scale.(Baseline)
- Reaction time(Baseline)