Neural and Physiological Responses to Real-World Experiences
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- inflammatory gene expression
研究概览
简要总结
UCLA researchers looking for healthy individuals (aged 35-50) who have a home computer with internet access, are not pregnant, planning to become pregnant, or currently breastfeeding (if female), to participate in a study investigating whether real-world experiences alter the brain and body. This study takes place over an eight week period and involves providing the names of 8 close friends or family members, completing a neuroimaging session, providing blood and saliva (for genetic analysis), and a 6-week period in which participants login twice a week to complete online questionnaires. Compensation is up to $210 for those who complete all aspects of the study. Please email realworld.ucla@gmail.com for more information.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 35 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults between the ages of 35-50
排除标准
- •Following a structured telephone interview, prospective participants with the following conditions will not be able to participate:
- •claustrophobia, left-handedness, or presence of metal in their body (for the neuroimaging procedures),
- •possible presence of a depressive disorder, which may interfere with the gratitude intervention (assessed by the Patient Health Questionnaire; Spitzer et al., 1999),
- •regular use of medications that may impact inflammatory processes (anti-inflammatory drugs, steroids, opioids),
- •current smokers or excessive caffeine users (> 600 mg/day) because of known effects on inflammation, and
- •pregnancy (which would affect oxytocin gene expression).
结局指标
主要结局
inflammatory gene expression
时间窗: baseline, six weeks post manipulation
Changes in inflammatory gene expression from pre- to post-intervention.
次要结局
- neural activity(baseline, six weeks post-intervention)
研究者
Naomi Eisenberger
Professor
University of California, Los Angeles