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临床试验/NCT03477136
NCT03477136Unknown不适用

Correlation of Serum and Semen Vitamin D Level With Semen Parameters in Males

Assiut University1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2018年12月6日最近更新:
适应症

试验速览

阶段
不适用
入组人数
150
试验地点
1
主要终点
correlation of serum and semen vitamin D level with semen parameters in males

研究概览

简要总结

vitamin D may have multiple functions, one of them is modulating reproductive processes and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptors in testis, male reproductive tract and sperms

详细描述

Semen analysis is the corner stone of infertility evaluation as it provides information on the functional status of the seminiferous tubules, epididymis and accessory sex glands. The methods on how the semen should be evaluated are provided by the World Health Organization Vitamin D is synthesized mainly in the skin, where ultraviolet ray B radiation converts 7-dehydrocholesterol to Vitamin D3. Then, Vitamin D3 undergoes two hydroxylation processes first in the liver and second in the kidney Serum 25(OH)D is the major circulating metabolite of vitamin D and reflects vitamin D inputs from cutaneous synthesis and dietary intake. The serum 25(OH)D level is the standard clinical measure of vitamin D status Vitamin D deficiency has been linked to various health disorders including boneheallth, cardiovascular, infectious, oncologic, musculoskeletal, neuropsychologic and reproductive disorders, as well as to overall mortality

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
20 Years 至 50 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • 未提供

排除标准

  • Varicocele.
  • Genital tract infections.
  • Primary and secondary hypogonadism
  • Hormonal therapy.
  • Calcium and vitamin D supplement.
  • Hepatic or renal failure
  • Diseases or drugs affecting vitamin D absorption -

结局指标

主要结局

correlation of serum and semen vitamin D level with semen parameters in males

时间窗: A year

evaluation the level of vitamin D in serum and semen by using ELISA method and correlate it with semen parameters

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mary Yonan

Principal investigator

Assiut University

研究点 (1)

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