The role of the dopamine and opioid systems in pain-avoidance learning - dopamine, opioids and pain-avoidance learning

niversiteit Leiden0 个研究点目标入组 91 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

Trial is onging in other countries

•Healthy adult subjects with no history of neurological disorder/disease or chronic pain, and no counter-indications to 3 Tesla MRI or to levodopa or naltrexone, and no personal relationship with the researchers will be included in this study. All participants will be right-handed native-Dutch speakers with normal vision or contact lenses.

•Potential participants will be prescreened for contra-indications for 3 Tesla fMRI and levodopa/naltrexone, which include metal implants, heart arrhythmia, claustrophobia, glaucoma, hypertension and use of anti-depressants or psychotropic medication and possible pregnancy (in adult females). They will additionally be prescreened for head trauma, premature birth, learning disabilities, chronic pain, and history of neurological or psychiatric illness. Finally, left-handed
•individuals will be excluded from the study because some left-handers have substantially different brain organization relative to right-handers.

发起方

niversiteit Leiden