Comparative evaluation of hyaluronic acid impregnated mersilk, conventional mersilk and vicryl plus sutures following mandibular third molar surgery.

Mandibular third molar extraction is a common oral surgical procedure frequently associated with postoperative complications such as pain, edema, trismus, hematoma, prolonged bleeding, pyrexia, and alveolar osteitis. These adverse effects can delay recovery and increase the risk of secondary infections and chronic pain. Sutures are critical in promoting wound stability and healing. This single-blinded, randomized controlled clinical trial aims to evaluate the efficacy of 1.5% hyaluronic acid (HA)-impregnated 3-0 mersilk sutures compared to conventional 3-0 mersilk and 3-0 Vicryl Plus sutures in mandibular third molar surgery. A total of 84 extraction sites will be randomly allocated into three equal groups (n=28): HA-impregnated mersilk (Group I), vicryl Plus (Group II), and conventional mersilk (Group III). Randomization will be conducted via coin flip, and outcome assessment will be blinded. Clinical wound healing will be evaluated using Landry’s Healing Index on postoperative days 1, 3, and 7. Microbial colonization will be assessed by colony-forming unit (CFU) counts, and pain levels will be measured using the Visual Analog Scale (VAS).The study hypothesizes that HA-impregnated mersilk sutures will demonstrate superior outcomes in wound healing, microbial control, and pain reduction. HA’s anti-inflammatory and antimicrobial properties may enhance tissue regeneration and minimize postoperative complications, potentially improving patient recovery and overall clinical outcomes.