Regional Epidemiology of COVID-19 and Acute Kidney Injury in England
试验速览
- 阶段
- 不适用
- 入组人数
- 5,000
- 主要终点
- acute kidney injury
研究概览
简要总结
The COVID-19 pandemic has exposed the unwanted variation in outcomes as evidence by Public Health England's report on increased mortality in regions of the country. For example, UHDB, in East Midlands, has reported a high crude mortality as compared to other Trusts in the region.8 There may also have been variation in the incidence of complications of COVID-19 in the form of AKI, which may have influenced mortality. Variation in outcomes may be because of various factors - differing population demographics, underlying health conditions in the population, deprivation, physician preference and knowledge and ethnic diversity. Unwanted variation is care that is not consistent with a patient's preference or related to [their] underlying illness. It is important to understand the reason for unwanted variation in outcomes associated with COVID-19 to minimise patient harm and reduce morbidity and mortality.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 110 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •This study will have two work packages (WP). Work Package 1 (WP1): Regional epidemiology of COVID-19 in England All patients who are admitted to hospital with COVID-19 infection between 1st March 2020 and 30th June 2020 and who meet following criteria will be included
- •Diagnostic code for COVID-19 (U07.1) in any of the 20 diagnoses codes
- •Adult patients greater or equal to 18 years of age.
- •Work Package 2 (WP2): Epidemiology of COVID-19 associated AKI in England All patients who are admitted to hospital with acute kidney injury (AKI) between 1st March 2020 and 30th June 2020 and who meet following criteria will be included
- •Diagnostic code for AKI (N17) in any of the 20 diagnoses codes
- •Adult patients greater or equal to 18 years of age.
排除标准
- •The following patients will be excluded from the study
- •Patients not admitted to the hospital
- •Paediatric patients < 18 years of age
- •The following patients will be excluded from the study
- •Patients not admitted to the hospital
- •Paediatric patients < 18 years of age
- •Patients on chronic maintenance haemodialysis or peritoneal dialysis
结局指标
主要结局
acute kidney injury
时间窗: 30 days
Incidence of acute kidney injury in patients with COVID-19
All-cause mortality
时间窗: 30 days
In-hospital all cause mortality in patients with acute kidney injury and COVID-19
次要结局
- Mechanical ventilation(30 days)