NCT06890390招募中不适用
TSPO PET in the Evaluation of Neuroinflammation in Patients with Multiple System Atrophy
Min Zhao,MD1 个研究点 分布在 1 个国家目标入组 90 人开始时间: 2024年9月14日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Standard uptake value ratio(SUVR)
研究概览
简要总结
The aim of this study was to apply PET/MR techniques targeting TSPO to explore the temporal and spatial alterations characterizing neuroinflammation in MSA patients, and to assess its value as a biomarker for diagnostic typing, disease severity, and prognosis of MSA disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age> 35 years old, gender is not limited;
- •Clinically confirmed MSA and clinically probable MSA according to the 2022 MDS MSA diagnostic criteria;
- •all patients had been ruled out of polyQ disease by genetic testing;
- •Voluntarily participate in this study and sign the informed consent form.
排除标准
- •pregnancy or breastfeeding;
- •contraindications to MRI examination or inability to cooperate in completing neuroimaging examination;
- •previous history of other neurological disorders or presence of other organic intracranial lesions on neuroimaging that cannot be interpreted by MSA, such as epilepsy, trauma, tumors, or high-grade cerebral white matter degeneration (Fazekas grade 2 and above);
- •History of alcohol or drug abuse
结局指标
主要结局
Standard uptake value ratio(SUVR)
时间窗: From enrollment to the end of treatment at 4 weeks
次要结局
- H-Y stage(From enrollment to the end of treatment at 4 weeks)
- Wexner score(From enrollment to the end of treatment at 4 weeks)
- UMSARS(From enrollment to the end of treatment at 4 weeks)
- SCOPA-AUT(From enrollment to the end of treatment at 4 weeks)
- Frontal Assessment Battery(From enrollment to the end of treatment at 4 weeks)
- MoCA score(From enrollment to the end of treatment at 4 weeks)
- TSPO Single nucleotide polymorphism genotyping(From enrollment to the end of treatment at 4 weeks)
研究者
研究点 (1)
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