Molecular Analysis of IgE Antibodies in Walnut Allergic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 61
- 试验地点
- 2
- 主要终点
- numbers of patients with walnut allergy
研究概览
简要总结
Accurate diagnosis of food allergy depends on the identification of the causative allergenic molecule(s). The proposed study intends to investigate and compare the pattern of IgE antibody sensitisation in walnut allergic subjects from three different regions of Europe (south (SEU) and central/north (C/NEU), to evaluate the diagnostic utility of a panel of novel allergen reagents.
详细描述
Accurate diagnosis of food allergy depends on the identification of the causative allergenic molecule(s). Thus, full characterization of the major allergens of walnut and their clinical importance is an important undertaking.
The proposed study intends to investigate and compare the pattern of IgE antibody sensitisation in walnut allergic subjects from three different regions of Europe (south (SEU) and central/north (C/NEU), to evaluate the diagnostic utility of a panel of novel allergen reagents.
With a view towards improved in vitro diagnostic methods, we intend to evaluate the diagnostic potential of recombinant walnut allergens in patients with walnut allergy confirmed by a positive provocation or supported by a convincing history of anaphylactic reaction(s) to walnut in the past, patients with pollinosis but no symptoms of walnut allergy and non-atopic control subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 1 Year 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Signed informed consent
- •Group A: positive case history of allergic reaction(s) to walnut
- •Group B: positive case history of allergy to birch, grass or olive pollen and no case history of allergic reaction(s) to walnut
- •Group C: no case history of atopic disease
排除标准
- •Known pregnancy
- •Breast-feeding of infant
- •Treatment with the following drugs (or shortest interval between last treatment and food challenge or SPT):
- •corticosteroids (2 weeks): applied systemically, to the nose or locally on the skin test area.
- •antihistamines (3 days) except hydroxyzine (10 days)
- •betablocker agents (1 day)
- •angiotensin converting enzyme inhibitors (2 days)
- •Any major organic or infectious disease
结局指标
主要结局
numbers of patients with walnut allergy
时间窗: December 2012 to November 2017, up to 5 years
次要结局
未报告次要终点