NCT03089242已完成不适用
MicroRNAs in Acute Kidney Injury (MIRAKI) - a Pilotstudy -
Heinrich-Heine University, Duesseldorf1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2017年9月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- acute kidney injury
研究概览
简要总结
Profiling of microRNAs and long noncoding RNAs (lncRNAs) in patients undergoing cardiac surgery. Analysis: Prediction of acute kidney injury by plasma expression profile of microRNAs?
详细描述
In this pilot study we will include 150 patients undergoing cardiac surgery in a German university hospital. We will profile microRNA expression in plasma and urine before and at several timepoints after surgery. We will use a preselected panel of microRNAs and lncRNAs for analysis. Goal is to identify microRNAs/lncRNAs that are able to predict the occurence of AKI in these patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •cardiac surgery
排除标准
- •preexisting chronic kidney injury
- •inclusion in another study
- •pregnancy
- •Kidney transplantation in history
- •GFR < 30 ml/min (glomerular filtration rate)
- •ECLS therapy (extracorporal life support)
结局指标
主要结局
acute kidney injury
时间窗: 1 year
AKI Stadium II or III following cardiac surgery.
次要结局
未报告次要终点
研究者
Klinik für Anästhesiologie
PD Dr. Timo Brandenburger
Heinrich-Heine University, Duesseldorf
研究点 (1)
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